Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study
Abstract Background Cervical dystonia (CD) is characterized by involuntary contractions of the cervical muscles. Data on long-term effectiveness of deep brain stimulation (DBS) are rare. The aim of this study was to evaluate the longitudinal ten years treatment efficacy of DBS in the globus pallidus...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Neurological Research and Practice |
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| Online Access: | https://doi.org/10.1186/s42466-022-00214-8 |
| _version_ | 1828339646597169152 |
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| author | Clemens Jacksch Kirsten E. Zeuner Ann-Kristin Helmers Karsten Witt Günther Deuschl Steffen Paschen |
| author_facet | Clemens Jacksch Kirsten E. Zeuner Ann-Kristin Helmers Karsten Witt Günther Deuschl Steffen Paschen |
| author_sort | Clemens Jacksch |
| collection | DOAJ |
| description | Abstract Background Cervical dystonia (CD) is characterized by involuntary contractions of the cervical muscles. Data on long-term effectiveness of deep brain stimulation (DBS) are rare. The aim of this study was to evaluate the longitudinal ten years treatment efficacy of DBS in the globus pallidus internus (GPI). Methods A retrospective single-center data analysis was performed on patients with idiopathic CD, who were treated with GPI DBS for at least 10 years. TWSTR severity score and individual sub-items were compared between pre and post DBS surgery (n = 15) over time. Results There was a significant and persistent positive effect regarding the severity of TWSTRS between the conditions immediately before and 1, 5, and 10 years after establishment of GPI DBS (mean difference: 6.6–7 ± 1.6). Patients with increasing CD complexity showed a poorer response to established treatment forms, such as injection of botulinum toxin and were thus DBS candidates. Especially a predominant torticollis was significantly improved by DBS. Conclusion GPI DBS is an effective procedure especially in severely affected patients with a positive 10-year outcome. It should be considered in more complex CD-forms or predominant torticollis. |
| first_indexed | 2024-04-13T22:45:43Z |
| format | Article |
| id | doaj.art-92b76a79e67c4176b502c9269cf978b2 |
| institution | Directory Open Access Journal |
| issn | 2524-3489 |
| language | English |
| last_indexed | 2024-04-13T22:45:43Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Neurological Research and Practice |
| spelling | doaj.art-92b76a79e67c4176b502c9269cf978b22022-12-22T02:26:24ZengBMCNeurological Research and Practice2524-34892022-10-01411910.1186/s42466-022-00214-8Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric studyClemens Jacksch0Kirsten E. Zeuner1Ann-Kristin Helmers2Karsten Witt3Günther Deuschl4Steffen Paschen5Department of Neurology, Christian Albrechts-University of KielDepartment of Neurology, Christian Albrechts-University of KielDepartment of Neurosurgery, Christian Albrechts-University of KielDepartment of Neurology and Research Center Neurosensory Science, Carl Von Ossietzky University OldenburgDepartment of Neurology, Christian Albrechts-University of KielDepartment of Neurology, Christian Albrechts-University of KielAbstract Background Cervical dystonia (CD) is characterized by involuntary contractions of the cervical muscles. Data on long-term effectiveness of deep brain stimulation (DBS) are rare. The aim of this study was to evaluate the longitudinal ten years treatment efficacy of DBS in the globus pallidus internus (GPI). Methods A retrospective single-center data analysis was performed on patients with idiopathic CD, who were treated with GPI DBS for at least 10 years. TWSTR severity score and individual sub-items were compared between pre and post DBS surgery (n = 15) over time. Results There was a significant and persistent positive effect regarding the severity of TWSTRS between the conditions immediately before and 1, 5, and 10 years after establishment of GPI DBS (mean difference: 6.6–7 ± 1.6). Patients with increasing CD complexity showed a poorer response to established treatment forms, such as injection of botulinum toxin and were thus DBS candidates. Especially a predominant torticollis was significantly improved by DBS. Conclusion GPI DBS is an effective procedure especially in severely affected patients with a positive 10-year outcome. It should be considered in more complex CD-forms or predominant torticollis.https://doi.org/10.1186/s42466-022-00214-8Idiopathic cervical dystoniaDeep brain stimulationLong-term effectiveness |
| spellingShingle | Clemens Jacksch Kirsten E. Zeuner Ann-Kristin Helmers Karsten Witt Günther Deuschl Steffen Paschen Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study Neurological Research and Practice Idiopathic cervical dystonia Deep brain stimulation Long-term effectiveness |
| title | Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study |
| title_full | Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study |
| title_fullStr | Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study |
| title_full_unstemmed | Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study |
| title_short | Long-term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia: a retrospective monocentric study |
| title_sort | long term efficacy with deep brain stimulation of the globus pallidus internus in cervical dystonia a retrospective monocentric study |
| topic | Idiopathic cervical dystonia Deep brain stimulation Long-term effectiveness |
| url | https://doi.org/10.1186/s42466-022-00214-8 |
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