Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study
This study, carried out on 94 women with polycystic ovary syndrome (PCOS) and 176 controls without it, investigated the influence of body mass index (BMI) on serum levels of antimüllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and 17ß-estradiol (E2) in infertile...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Reproductive Medicine |
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| Online Access: | https://www.mdpi.com/2673-3897/4/3/18 |
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| author | Luisa Casadei Ilaria Nacci Veronica Vicomandi Roberto Pietro Sorge Carlo Ticconi |
| author_facet | Luisa Casadei Ilaria Nacci Veronica Vicomandi Roberto Pietro Sorge Carlo Ticconi |
| author_sort | Luisa Casadei |
| collection | DOAJ |
| description | This study, carried out on 94 women with polycystic ovary syndrome (PCOS) and 176 controls without it, investigated the influence of body mass index (BMI) on serum levels of antimüllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and 17ß-estradiol (E2) in infertile patients. Patients were assigned to four subgroups according to age (<35 or ≥35 years) and BMI (<25 kg/m<sup>2</sup> or ≥25 kg/m<sup>2</sup>). Significant differences between PCOS-affected and control women were observed with respect to most of the parameters of interest. In both PCOS-affected and control women, age was inversely correlated with AMH. In the control patients, age was directly correlated with FSH and LH. In women affected by PCOS, no correlation was found between BMI and serum levels of AMH, E2, and LH, except FSH. No correlation was found between BMI and markers of ovarian reserve in control women. BMI was not correlated with AMH in any of the four subgroups considered regardless of the presence of PCOS. An inverse correlation was found only in PCOS-affected women aged ≥35 years between a BMI < 25/FSH and a BMI ≥ 25/LH. The possible association between BMI and ovulation disorder (OD) was investigated in 96 control women aged ≤37 years. In women with OD, the BMI values were significantly higher and FSH and E2 levels were lower than those of patients without OD. Taken together, our data suggest that BMI is not related to hormonal parameters of ovarian reserve, irrespective of the presence of PCOS, and could influence ovulation disorder rather than cause a decrease in ovarian reserve. |
| first_indexed | 2024-03-10T22:04:28Z |
| format | Article |
| id | doaj.art-92b77189b11d4319919ffe626d75bda3 |
| institution | Directory Open Access Journal |
| issn | 2673-3897 |
| language | English |
| last_indexed | 2024-03-10T22:04:28Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reproductive Medicine |
| spelling | doaj.art-92b77189b11d4319919ffe626d75bda32023-11-19T12:50:53ZengMDPI AGReproductive Medicine2673-38972023-08-014319820910.3390/reprodmed4030018Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control StudyLuisa Casadei0Ilaria Nacci1Veronica Vicomandi2Roberto Pietro Sorge3Carlo Ticconi4Academic Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, ItalyAcademic Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, ItalyAcademic Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, ItalyLaboratory of Biometry, Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, ItalyAcademic Department of Surgical Sciences, Section of Gynecology and Obstetrics, University of Rome Tor Vergata, Via Montpellier, 1, 00133 Rome, ItalyThis study, carried out on 94 women with polycystic ovary syndrome (PCOS) and 176 controls without it, investigated the influence of body mass index (BMI) on serum levels of antimüllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and 17ß-estradiol (E2) in infertile patients. Patients were assigned to four subgroups according to age (<35 or ≥35 years) and BMI (<25 kg/m<sup>2</sup> or ≥25 kg/m<sup>2</sup>). Significant differences between PCOS-affected and control women were observed with respect to most of the parameters of interest. In both PCOS-affected and control women, age was inversely correlated with AMH. In the control patients, age was directly correlated with FSH and LH. In women affected by PCOS, no correlation was found between BMI and serum levels of AMH, E2, and LH, except FSH. No correlation was found between BMI and markers of ovarian reserve in control women. BMI was not correlated with AMH in any of the four subgroups considered regardless of the presence of PCOS. An inverse correlation was found only in PCOS-affected women aged ≥35 years between a BMI < 25/FSH and a BMI ≥ 25/LH. The possible association between BMI and ovulation disorder (OD) was investigated in 96 control women aged ≤37 years. In women with OD, the BMI values were significantly higher and FSH and E2 levels were lower than those of patients without OD. Taken together, our data suggest that BMI is not related to hormonal parameters of ovarian reserve, irrespective of the presence of PCOS, and could influence ovulation disorder rather than cause a decrease in ovarian reserve.https://www.mdpi.com/2673-3897/4/3/18anti-Müllerian hormonebody mass indexovarian reserveovulationpolycystic ovarian syndrome |
| spellingShingle | Luisa Casadei Ilaria Nacci Veronica Vicomandi Roberto Pietro Sorge Carlo Ticconi Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study Reproductive Medicine anti-Müllerian hormone body mass index ovarian reserve ovulation polycystic ovarian syndrome |
| title | Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study |
| title_full | Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study |
| title_fullStr | Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study |
| title_full_unstemmed | Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study |
| title_short | Relationship between Ovarian Reserve Markers and Body Mass Index in Infertile Women with and without Polycystic Ovary Syndrome: A Retrospective Case–Control Study |
| title_sort | relationship between ovarian reserve markers and body mass index in infertile women with and without polycystic ovary syndrome a retrospective case control study |
| topic | anti-Müllerian hormone body mass index ovarian reserve ovulation polycystic ovarian syndrome |
| url | https://www.mdpi.com/2673-3897/4/3/18 |
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