PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.

PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition.

<h4>Background</h4>Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense mutations (PIK3CAmut) in GBM are restricted to three functional domains: adaptor binding (ABD), helical, and kinase. D...

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Main Authors: Robert S McNeill, Emily E Stroobant, Erin Smithberger, Demitra A Canoutas, Madison K Butler, Abigail K Shelton, Shrey D Patel, Juanita C Limas, Kasey R Skinner, Ryan E Bash, Ralf S Schmid, C Ryan Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0200014

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