Modelling HIV infection and therapies in humanised mice
The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newb...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2012-07-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/1519 |
| _version_ | 1811289175553474560 |
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| author | Marc Nischang Gustavo Gers-Huber Annette Audigé Ramesh Akkina Roberto F Speck |
| author_facet | Marc Nischang Gustavo Gers-Huber Annette Audigé Ramesh Akkina Roberto F Speck |
| author_sort | Marc Nischang |
| collection | DOAJ |
| description |
The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection.
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| first_indexed | 2024-04-13T03:50:15Z |
| format | Article |
| id | doaj.art-92b86a459ec747aaa562e8515c8c7ef1 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2024-04-13T03:50:15Z |
| publishDate | 2012-07-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-92b86a459ec747aaa562e8515c8c7ef12022-12-22T03:03:51ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972012-07-01142272810.4414/smw.2012.13618Modelling HIV infection and therapies in humanised miceMarc NischangGustavo Gers-HuberAnnette AudigéRamesh AkkinaRoberto F Speck The human immunodeficiency virus (HIV) type-1 is a human-specific virus. The lack of a widely available small-animal model has seriously hampered HIV research. In 2004, a new humanised mouse model was reported. It was based on the intrahepatic injection of human CD34+ cord blood cells into newborn, highly immunodeficient mice. These mice develop a lymphoid system of human origin and are highly susceptible to HIV infection and showed disseminated infection, persistent viraemia and characteristic helper CD4+ T-cell loss. Here, we will briefly review the various existing humanised mouse models and highlight their value to the study of HIV infection. https://www.smw.ch/index.php/smw/article/view/1519antiretroviral treatmentBLT miceCCR5gene therapyHIV pathogenesisHIV pre-exposure prophylaxis (PrEP) |
| spellingShingle | Marc Nischang Gustavo Gers-Huber Annette Audigé Ramesh Akkina Roberto F Speck Modelling HIV infection and therapies in humanised mice Swiss Medical Weekly antiretroviral treatment BLT mice CCR5 gene therapy HIV pathogenesis HIV pre-exposure prophylaxis (PrEP) |
| title | Modelling HIV infection and therapies in humanised mice |
| title_full | Modelling HIV infection and therapies in humanised mice |
| title_fullStr | Modelling HIV infection and therapies in humanised mice |
| title_full_unstemmed | Modelling HIV infection and therapies in humanised mice |
| title_short | Modelling HIV infection and therapies in humanised mice |
| title_sort | modelling hiv infection and therapies in humanised mice |
| topic | antiretroviral treatment BLT mice CCR5 gene therapy HIV pathogenesis HIV pre-exposure prophylaxis (PrEP) |
| url | https://www.smw.ch/index.php/smw/article/view/1519 |
| work_keys_str_mv | AT marcnischang modellinghivinfectionandtherapiesinhumanisedmice AT gustavogershuber modellinghivinfectionandtherapiesinhumanisedmice AT annetteaudige modellinghivinfectionandtherapiesinhumanisedmice AT rameshakkina modellinghivinfectionandtherapiesinhumanisedmice AT robertofspeck modellinghivinfectionandtherapiesinhumanisedmice |