MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

MCF10CA Breast Cancer Cells Utilize Hyaluronan-Coated EV-Rich Trails for Coordinated Migration

Invasion of tumor cells through the stroma is coordinated in response to migratory cues provided by the extracellular environment. One of the most abundant molecules in the tumor microenvironment is hyaluronan, a glycosaminoglycan known to promote many hallmarks of tumor progression, including the m...

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Bibliographic Details
Main Authors: Niina Aaltonen, Heikki Kyykallio, Sylvain Tollis, Janne Capra, Jaana M. Hartikainen, Johanna Matilainen, Sanna Oikari, Kirsi Rilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
hyaluronan
breast cancer
extracellular vesicle (EV)
migration
filopodia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.869417/full

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