Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer
Abstract Objective Clinical outcomes of infection by S. gallolyticus have not been investigated extensively. We aimed to determine the prevalence of S. gallolyticus in tumor specimens obtained from Iranian patients diagnosed with colorectal cancer. Polymerase chain reaction was used to confirm the p...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-022-06207-9 |
| _version_ | 1817984808911896576 |
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| author | Negin Kamali Amin Talebi Bezmin Abadi Bezmin Abadi Farid Rahimi Mojgan Forootan |
| author_facet | Negin Kamali Amin Talebi Bezmin Abadi Bezmin Abadi Farid Rahimi Mojgan Forootan |
| author_sort | Negin Kamali |
| collection | DOAJ |
| description | Abstract Objective Clinical outcomes of infection by S. gallolyticus have not been investigated extensively. We aimed to determine the prevalence of S. gallolyticus in tumor specimens obtained from Iranian patients diagnosed with colorectal cancer. Polymerase chain reaction was used to confirm the presence of S. gallolyticus in patients’ tissue samples. Results Of 176 patients, 65 were diagnosed with colorectal cancer whereas 111 did not have any colon disease. No correlation was found between age, colonization with S. gallolyticus, gender, or risk factors. Overall, 72 (40%) patients carried S. gallolyticus; only 29% of the patients without colorectal cancer were positive for S. gallolyticus. Diagnosis of colorectal cancer and presence of S. gallolyticus significantly correlated (P = 0.006; odds ratio = 1.46; 95% CI = 1.21–3.87). Among the patients with colorectal cancer, 39 (60%) were positive with S. gallolyticus (P = 0.006) whereas 33 of 111 (29.7%) control subjects were positive for S. gallolyticus (P > 0.05); thus, 70.3% of the control subjects were not infected with S. gallolyticus. We found a high prevalence of S. gallolyticus among an Iranian cohort of patients with colorectal cancer. Despite previous reports, we report a positive correlation between colorectal cancer and S. gallolyticus colonization. |
| first_indexed | 2024-04-13T23:50:04Z |
| format | Article |
| id | doaj.art-92ba70d37ca54cbfae87da5a5a531980 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-13T23:50:04Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-92ba70d37ca54cbfae87da5a5a5319802022-12-22T02:24:09ZengBMCBMC Research Notes1756-05002022-10-011511410.1186/s13104-022-06207-9Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancerNegin Kamali0Amin Talebi Bezmin Abadi1Bezmin Abadi2Farid Rahimi3Mojgan Forootan4Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares UniversityResearch School of Biology, The Australian National University, Ngunnawal and Ngambri CountryGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical SciencesAbstract Objective Clinical outcomes of infection by S. gallolyticus have not been investigated extensively. We aimed to determine the prevalence of S. gallolyticus in tumor specimens obtained from Iranian patients diagnosed with colorectal cancer. Polymerase chain reaction was used to confirm the presence of S. gallolyticus in patients’ tissue samples. Results Of 176 patients, 65 were diagnosed with colorectal cancer whereas 111 did not have any colon disease. No correlation was found between age, colonization with S. gallolyticus, gender, or risk factors. Overall, 72 (40%) patients carried S. gallolyticus; only 29% of the patients without colorectal cancer were positive for S. gallolyticus. Diagnosis of colorectal cancer and presence of S. gallolyticus significantly correlated (P = 0.006; odds ratio = 1.46; 95% CI = 1.21–3.87). Among the patients with colorectal cancer, 39 (60%) were positive with S. gallolyticus (P = 0.006) whereas 33 of 111 (29.7%) control subjects were positive for S. gallolyticus (P > 0.05); thus, 70.3% of the control subjects were not infected with S. gallolyticus. We found a high prevalence of S. gallolyticus among an Iranian cohort of patients with colorectal cancer. Despite previous reports, we report a positive correlation between colorectal cancer and S. gallolyticus colonization.https://doi.org/10.1186/s13104-022-06207-9Colorectal cancerCorrelationIranPCRStreptococcus gallolyticus |
| spellingShingle | Negin Kamali Amin Talebi Bezmin Abadi Bezmin Abadi Farid Rahimi Mojgan Forootan Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer BMC Research Notes Colorectal cancer Correlation Iran PCR Streptococcus gallolyticus |
| title | Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer |
| title_full | Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer |
| title_fullStr | Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer |
| title_full_unstemmed | Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer |
| title_short | Identification of Streptococcus gallolyticus in tumor samples of Iranian patients diagnosed with colorectal cancer |
| title_sort | identification of streptococcus gallolyticus in tumor samples of iranian patients diagnosed with colorectal cancer |
| topic | Colorectal cancer Correlation Iran PCR Streptococcus gallolyticus |
| url | https://doi.org/10.1186/s13104-022-06207-9 |
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