Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase

Mupirocin blocks imiquimod-induced psoriasis-like skin lesion by inhibiting epidermal isoleucyl-tRNA synthetase

Abstract Background The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aimed to investigate the mechanisms underlying the efficacy of IARS inhibit...

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Bibliographic Details
Main Authors: Bing-Xi Yan, Xue-Yan Chen, Zhao-Yuan Wang, Ying-Zhe Cui, Lilla Landeck, Ni-Chang Fu, Xing-Yu Yang, Fan Xu, Yuan Zhou, Jia-Qi Chen, Xiao-Yong Man
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cell Communication and Signaling
Subjects:
Mupirocin
Imiquimod
IARS
Psoriasis
Online Access:https://doi.org/10.1186/s12964-022-00995-0

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