Peptides and Peptidomimetics for Antimicrobial Drug Design
The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial p...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-07-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/8/3/366 |
| _version_ | 1818324578432188416 |
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| author | Biljana Mojsoska Håvard Jenssen |
| author_facet | Biljana Mojsoska Håvard Jenssen |
| author_sort | Biljana Mojsoska |
| collection | DOAJ |
| description | The purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics. |
| first_indexed | 2024-12-13T11:30:49Z |
| format | Article |
| id | doaj.art-92bb3a49fc0142239be75d8027d37cb5 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-13T11:30:49Z |
| publishDate | 2015-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-92bb3a49fc0142239be75d8027d37cb52022-12-21T23:47:57ZengMDPI AGPharmaceuticals1424-82472015-07-018336641510.3390/ph8030366ph8030366Peptides and Peptidomimetics for Antimicrobial Drug DesignBiljana Mojsoska0Håvard Jenssen1Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, Postboks 260, Roskilde 4000, DenmarkDepartment of Science, Systems and Models, Roskilde University, Universitetsvej 1, Postboks 260, Roskilde 4000, DenmarkThe purpose of this paper is to introduce and highlight a few classes of traditional antimicrobial peptides with a focus on structure-activity relationship studies. After first dissecting the important physiochemical properties that influence the antimicrobial and toxic properties of antimicrobial peptides, the contributions of individual amino acids with respect to the peptides antibacterial properties are presented. A brief discussion of the mechanisms of action of different antimicrobials as well as the development of bacterial resistance towards antimicrobial peptides follows. Finally, current efforts on novel design strategies and peptidomimetics are introduced to illustrate the importance of antimicrobial peptide research in the development of future antibiotics.http://www.mdpi.com/1424-8247/8/3/366antimicrobial peptidesmechanism of actionpeptidomimetics |
| spellingShingle | Biljana Mojsoska Håvard Jenssen Peptides and Peptidomimetics for Antimicrobial Drug Design Pharmaceuticals antimicrobial peptides mechanism of action peptidomimetics |
| title | Peptides and Peptidomimetics for Antimicrobial Drug Design |
| title_full | Peptides and Peptidomimetics for Antimicrobial Drug Design |
| title_fullStr | Peptides and Peptidomimetics for Antimicrobial Drug Design |
| title_full_unstemmed | Peptides and Peptidomimetics for Antimicrobial Drug Design |
| title_short | Peptides and Peptidomimetics for Antimicrobial Drug Design |
| title_sort | peptides and peptidomimetics for antimicrobial drug design |
| topic | antimicrobial peptides mechanism of action peptidomimetics |
| url | http://www.mdpi.com/1424-8247/8/3/366 |
| work_keys_str_mv | AT biljanamojsoska peptidesandpeptidomimeticsforantimicrobialdrugdesign AT havardjenssen peptidesandpeptidomimeticsforantimicrobialdrugdesign |