| Summary: | Stroke is a leading cause of death and disability world-widely. The incidence
rate of stroke has been increasing due to the aging population and lifestyle
changes. At present, the only drug approved by the US Food and Drug
Administration (FDA) for the treatment of ischemic stroke is tissue plasminogen
activator (t-PA), but its clinical application is greatly limited because of its
narrow time window and bleeding risk. Natural products have a long history of
being used in traditional medicine with good safety, making them an important
resource for the development of new drugs. Indeed, some natural products can
target a variety of pathophysiological processes related to stroke, including
oxidative stress, inflammation and neuronal apoptosis. Therefore, the development
of high-efficiency, low-toxicity, safe and cheap active substances from natural
products is of great significance for improving the treatment alternatives of
patients with stroke. This article reviews the neuroprotective effects of 33
natural compounds by searching recent related literature. Among them, puerarin,
pinocembrin, quercetin, epigallocatechin-3-gallate (EGCG), and resveratrol have
great potential in the clinical treatment of ischemic stroke. This review will
provide a powerful reference for screening natural compounds with potential
clinical application value in ischemic stroke or synthesizing new neuroprotective
agents with natural compounds as lead compounds.
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