The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm

The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm

Parthenolide (PTL or PAR) was first isolated from Magnolia grandiflora and identified as a small molecule cancer inhibitor. PTL has the chemical structure of C15H20O3 with characteristics of sesquiterpene lactones and exhibits the biological property of inhibiting DNA biosynthesis of cancer cells. I...

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Bibliographic Details
Main Authors: Sipin Zhu, Ping Sun, Samuel Bennett, Oscar Charlesworth, Renxiang Tan, Xing Peng, Qiang Gu, Omar Kujan, Jiake Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
parthenolide
skeletal diseases
cancers
inflammation
osteolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1111218/full

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