NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases

NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases

Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal functions could help the search for much-needed analgesics. Towards this goal, cultured neurons from neonatal rat trigeminal ganglia—a locus for...

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Bibliographic Details
Main Authors: Mariia Belinskaia, Tomas Zurawski, Seshu Kumar Kaza, Caren Antoniazzi, J. Oliver Dolly, Gary W. Lawrence
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
botulinum neurotoxins
trigeminal ganglion neurons
nociceptor sensitisation
nerve growth factor
capsaicin
calcitonin gene-related peptide
Online Access:https://www.mdpi.com/1422-0067/23/2/892

Internet

https://www.mdpi.com/1422-0067/23/2/892

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