Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions
Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide, which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC). Even though current approved antiviral therapies, including pegylated type I interferon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/5/777 |
| _version_ | 1797536062292099072 |
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| author | Yongzhen Liu Stephanie Maya Alexander Ploss |
| author_facet | Yongzhen Liu Stephanie Maya Alexander Ploss |
| author_sort | Yongzhen Liu |
| collection | DOAJ |
| description | Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide, which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC). Even though current approved antiviral therapies, including pegylated type I interferon (IFN) and nucleos(t)ide analogs, can effectively suppress viremia, HBV infection is rarely cured. Since HBV exhibits a narrow species tropism and robustly infects only humans and higher primates, progress in HBV research and preclinical testing of antiviral drugs has been hampered by the scarcity of suitable animal models. Fortunately, a series of surrogate animal models have been developed for the study of HBV. An increased understanding of the barriers towards interspecies transmission has aided in the development of human chimeric mice and has greatly paved the way for HBV research in vivo, and for evaluating potential therapies of chronic hepatitis B. In this review, we summarize the currently available animal models for research of HBV and HBV-related hepadnaviruses, and we discuss challenges and future directions for improvement. |
| first_indexed | 2024-03-10T11:54:17Z |
| format | Article |
| id | doaj.art-92c0fe052a70400c9926ec713086c8c5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T11:54:17Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-92c0fe052a70400c9926ec713086c8c52023-11-21T17:29:41ZengMDPI AGViruses1999-49152021-04-0113577710.3390/v13050777Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future DirectionsYongzhen Liu0Stephanie Maya1Alexander Ploss2110 Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey, NJ 11 08544-101, USA110 Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey, NJ 11 08544-101, USA110 Lewis Thomas Laboratory, Department of Molecular Biology, Princeton University, Washington Road, Princeton, New Jersey, NJ 11 08544-101, USAChronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide, which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC). Even though current approved antiviral therapies, including pegylated type I interferon (IFN) and nucleos(t)ide analogs, can effectively suppress viremia, HBV infection is rarely cured. Since HBV exhibits a narrow species tropism and robustly infects only humans and higher primates, progress in HBV research and preclinical testing of antiviral drugs has been hampered by the scarcity of suitable animal models. Fortunately, a series of surrogate animal models have been developed for the study of HBV. An increased understanding of the barriers towards interspecies transmission has aided in the development of human chimeric mice and has greatly paved the way for HBV research in vivo, and for evaluating potential therapies of chronic hepatitis B. In this review, we summarize the currently available animal models for research of HBV and HBV-related hepadnaviruses, and we discuss challenges and future directions for improvement.https://www.mdpi.com/1999-4915/13/5/777hepatitis B virushepatitis Banimal modelspecies tropismhumanized mice |
| spellingShingle | Yongzhen Liu Stephanie Maya Alexander Ploss Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions Viruses hepatitis B virus hepatitis B animal model species tropism humanized mice |
| title | Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions |
| title_full | Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions |
| title_fullStr | Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions |
| title_full_unstemmed | Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions |
| title_short | Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions |
| title_sort | animal models of hepatitis b virus infection success challenges and future directions |
| topic | hepatitis B virus hepatitis B animal model species tropism humanized mice |
| url | https://www.mdpi.com/1999-4915/13/5/777 |
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