Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster
Memory performance depends not only on effective learning and storage of information, but also on its efficient retrieval. In Drosophila, aversive olfactory conditioning generates qualitatively different forms of memory depending on the number and spacing of conditioning trials. However, it is not k...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00192/full |
| _version_ | 1819123483427209216 |
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| author | Marie-Ange eCHABAUD Marie-Ange eCHABAUD Thomas ePREAT Thomas ePREAT Laure KAISER Laure KAISER Laure KAISER |
| author_facet | Marie-Ange eCHABAUD Marie-Ange eCHABAUD Thomas ePREAT Thomas ePREAT Laure KAISER Laure KAISER Laure KAISER |
| author_sort | Marie-Ange eCHABAUD |
| collection | DOAJ |
| description | Memory performance depends not only on effective learning and storage of information, but also on its efficient retrieval. In Drosophila, aversive olfactory conditioning generates qualitatively different forms of memory depending on the number and spacing of conditioning trials. However, it is not known how these differences are reflected at the retrieval level, in the behavior of individual flies during testing. We analyzed conditioned behaviors after one conditioning trial and after massed and spaced repeated trials. The single conditioning produces an early memory that was tested at 1.5 h. Tested at 24h after training, the spaced and the massed protocols generate two different forms of consolidated memory, dependent or independent of de novo protein-synthesis. We found clearly distinct patterns of locomotor activity in flies trained with either spaced or massed conditioning protocols. Spaced-trained flies exhibited immediate and dynamic choices between punished and unpunished odors during the test, whereas massed-trained flies made a delayed choice and showed earlier disappearance of the conditioned response. Flies trained with single and spaced trials responded to the punished odor by decreasing their resting time, but not massed-trained flies. These findings demonstrate that genetically and pharmacologically distinct forms of memory drive characteristically different forms of locomotor behavior during retrieval, and they may shed light on our previous observation that memory retrieval in massed-trained flies is socially facilitated. Social interactions would enhance exploratory activity, and then reduce the latency of their conditioned choice and delay its extinction. |
| first_indexed | 2024-12-22T07:09:04Z |
| format | Article |
| id | doaj.art-92c1750bd08b431c8aa4db37e338d418 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-22T07:09:04Z |
| publishDate | 2010-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-92c1750bd08b431c8aa4db37e338d4182022-12-21T18:34:34ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532010-12-01410.3389/fnbeh.2010.001922014Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogasterMarie-Ange eCHABAUD0Marie-Ange eCHABAUD1Thomas ePREAT2Thomas ePREAT3Laure KAISER4Laure KAISER5Laure KAISER6INRACNRSUMR 7637,CNRS and ESPCICNRSUPR9034,CNRS, Université Paris-Sud 11 and IRDCNRSINRAMemory performance depends not only on effective learning and storage of information, but also on its efficient retrieval. In Drosophila, aversive olfactory conditioning generates qualitatively different forms of memory depending on the number and spacing of conditioning trials. However, it is not known how these differences are reflected at the retrieval level, in the behavior of individual flies during testing. We analyzed conditioned behaviors after one conditioning trial and after massed and spaced repeated trials. The single conditioning produces an early memory that was tested at 1.5 h. Tested at 24h after training, the spaced and the massed protocols generate two different forms of consolidated memory, dependent or independent of de novo protein-synthesis. We found clearly distinct patterns of locomotor activity in flies trained with either spaced or massed conditioning protocols. Spaced-trained flies exhibited immediate and dynamic choices between punished and unpunished odors during the test, whereas massed-trained flies made a delayed choice and showed earlier disappearance of the conditioned response. Flies trained with single and spaced trials responded to the punished odor by decreasing their resting time, but not massed-trained flies. These findings demonstrate that genetically and pharmacologically distinct forms of memory drive characteristically different forms of locomotor behavior during retrieval, and they may shed light on our previous observation that memory retrieval in massed-trained flies is socially facilitated. Social interactions would enhance exploratory activity, and then reduce the latency of their conditioned choice and delay its extinction.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00192/fullLocomotionMemoryinsectchoiceodorconditioning |
| spellingShingle | Marie-Ange eCHABAUD Marie-Ange eCHABAUD Thomas ePREAT Thomas ePREAT Laure KAISER Laure KAISER Laure KAISER Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster Frontiers in Behavioral Neuroscience Locomotion Memory insect choice odor conditioning |
| title | Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster |
| title_full | Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster |
| title_fullStr | Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster |
| title_full_unstemmed | Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster |
| title_short | Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster |
| title_sort | behavioral characterization of individual olfactory memory retrieval in drosophila melanogaster |
| topic | Locomotion Memory insect choice odor conditioning |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2010.00192/full |
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