Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Abstract Nonalcoholic fatty liver disease is a growing epidemic affecting 30% of the adult population in the Western world. Its progressive form, nonalcoholic steatohepatitis (NASH), is associated with an increased risk of advanced fibrosis, cirrhosis and liver‐related mortality. Therefore, the dete...
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.134 |
| _version_ | 1818203058662801408 |
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| author | Cyrielle Caussy Lars Johansson |
| author_facet | Cyrielle Caussy Lars Johansson |
| author_sort | Cyrielle Caussy |
| collection | DOAJ |
| description | Abstract Nonalcoholic fatty liver disease is a growing epidemic affecting 30% of the adult population in the Western world. Its progressive form, nonalcoholic steatohepatitis (NASH), is associated with an increased risk of advanced fibrosis, cirrhosis and liver‐related mortality. Therefore, the detection of NAFLD and risk stratification according to the severity of the disease is crucial for the management of patients with NAFLD. Liver biopsy for such risk stratification strategies is limited by its cost and risks; therefore, noninvasive alternatives have been developed. Among noninvasive biomarkers developed in NAFLD, magnetic resonance (MR)‐based biomarkers have emerged as key noninvasive biomarkers in NAFLD with the ability to accurately detect hepatic steatosis and liver fibrosis. The potential utility of MRI for the detection of NASH and functional liver assessment has also recently emerged. In the current review, we will discuss the data supporting the utility of MR‐based biomarker for the detection of features of NAFLD and its potential use in clinical practice and clinical research in NAFLD. |
| first_indexed | 2024-12-12T03:19:19Z |
| format | Article |
| id | doaj.art-92c177b2cb004ff7848b848728456036 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-12-12T03:19:19Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-92c177b2cb004ff7848b8487284560362022-12-22T00:40:13ZengWileyEndocrinology, Diabetes & Metabolism2398-92382020-10-0134n/an/a10.1002/edm2.134Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitisCyrielle Caussy0Lars Johansson1Univ Lyon CarMen Laboratory INSERM INRA INSA Lyon Université Claude Bernard Lyon 1 Pierre‐Bénite FranceAntaros Medical Bioventure Hub Mölndal SwedenAbstract Nonalcoholic fatty liver disease is a growing epidemic affecting 30% of the adult population in the Western world. Its progressive form, nonalcoholic steatohepatitis (NASH), is associated with an increased risk of advanced fibrosis, cirrhosis and liver‐related mortality. Therefore, the detection of NAFLD and risk stratification according to the severity of the disease is crucial for the management of patients with NAFLD. Liver biopsy for such risk stratification strategies is limited by its cost and risks; therefore, noninvasive alternatives have been developed. Among noninvasive biomarkers developed in NAFLD, magnetic resonance (MR)‐based biomarkers have emerged as key noninvasive biomarkers in NAFLD with the ability to accurately detect hepatic steatosis and liver fibrosis. The potential utility of MRI for the detection of NASH and functional liver assessment has also recently emerged. In the current review, we will discuss the data supporting the utility of MR‐based biomarker for the detection of features of NAFLD and its potential use in clinical practice and clinical research in NAFLD.https://doi.org/10.1002/edm2.134elastographyhepatic steatosismagnetic resonance imagingNAFLDNASH |
| spellingShingle | Cyrielle Caussy Lars Johansson Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis Endocrinology, Diabetes & Metabolism elastography hepatic steatosis magnetic resonance imaging NAFLD NASH |
| title | Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis |
| title_full | Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis |
| title_fullStr | Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis |
| title_full_unstemmed | Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis |
| title_short | Magnetic resonance‐based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis |
| title_sort | magnetic resonance based biomarkers in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis |
| topic | elastography hepatic steatosis magnetic resonance imaging NAFLD NASH |
| url | https://doi.org/10.1002/edm2.134 |
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