Novel Nano-Drug Delivery System for Brain Tumor Treatment
As the most dangerous tumors, brain tumors are usually treated with surgical removal, radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas and their resistance to conventional chemoradiotherapy, it is difficult to cure brain tumors by conventional means. In addition,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/23/3761 |
| _version_ | 1797463493439389696 |
|---|---|
| author | Ziyi Qiu Zhenhua Yu Ting Xu Liuyou Wang Nanxin Meng Huawei Jin Bingzhe Xu |
| author_facet | Ziyi Qiu Zhenhua Yu Ting Xu Liuyou Wang Nanxin Meng Huawei Jin Bingzhe Xu |
| author_sort | Ziyi Qiu |
| collection | DOAJ |
| description | As the most dangerous tumors, brain tumors are usually treated with surgical removal, radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas and their resistance to conventional chemoradiotherapy, it is difficult to cure brain tumors by conventional means. In addition, the higher dose requirement of chemotherapeutic drugs caused by the blood–brain barrier (BBB) and the untargeted nature of the drug inevitably leads to low efficacy and systemic toxicity of chemotherapy. In recent years, nanodrug carriers have attracted extensive attention because of their superior drug transport capacity and easy-to-control properties. This review systematically summarizes the major strategies of novel nano-drug delivery systems for the treatment of brain tumors in recent years that cross the BBB and enhance brain targeting, and compares the advantages and disadvantages of several strategies. |
| first_indexed | 2024-03-09T17:51:29Z |
| format | Article |
| id | doaj.art-92c1db0d11cc41838e15a920f7142efc |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T17:51:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-92c1db0d11cc41838e15a920f7142efc2023-11-24T10:43:23ZengMDPI AGCells2073-44092022-11-011123376110.3390/cells11233761Novel Nano-Drug Delivery System for Brain Tumor TreatmentZiyi Qiu0Zhenhua Yu1Ting Xu2Liuyou Wang3Nanxin Meng4Huawei Jin5Bingzhe Xu6School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaSun Yat-Sen University First Affiliated Hospital, Guangzhou 510060, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaSun Yat-Sen University First Affiliated Hospital, Guangzhou 510060, ChinaSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen 518107, ChinaAs the most dangerous tumors, brain tumors are usually treated with surgical removal, radiation therapy, and chemotherapy. However, due to the aggressive growth of gliomas and their resistance to conventional chemoradiotherapy, it is difficult to cure brain tumors by conventional means. In addition, the higher dose requirement of chemotherapeutic drugs caused by the blood–brain barrier (BBB) and the untargeted nature of the drug inevitably leads to low efficacy and systemic toxicity of chemotherapy. In recent years, nanodrug carriers have attracted extensive attention because of their superior drug transport capacity and easy-to-control properties. This review systematically summarizes the major strategies of novel nano-drug delivery systems for the treatment of brain tumors in recent years that cross the BBB and enhance brain targeting, and compares the advantages and disadvantages of several strategies.https://www.mdpi.com/2073-4409/11/23/3761gliomabrain tumorblood–brain barriernano-drug delivery systems |
| spellingShingle | Ziyi Qiu Zhenhua Yu Ting Xu Liuyou Wang Nanxin Meng Huawei Jin Bingzhe Xu Novel Nano-Drug Delivery System for Brain Tumor Treatment Cells glioma brain tumor blood–brain barrier nano-drug delivery systems |
| title | Novel Nano-Drug Delivery System for Brain Tumor Treatment |
| title_full | Novel Nano-Drug Delivery System for Brain Tumor Treatment |
| title_fullStr | Novel Nano-Drug Delivery System for Brain Tumor Treatment |
| title_full_unstemmed | Novel Nano-Drug Delivery System for Brain Tumor Treatment |
| title_short | Novel Nano-Drug Delivery System for Brain Tumor Treatment |
| title_sort | novel nano drug delivery system for brain tumor treatment |
| topic | glioma brain tumor blood–brain barrier nano-drug delivery systems |
| url | https://www.mdpi.com/2073-4409/11/23/3761 |
| work_keys_str_mv | AT ziyiqiu novelnanodrugdeliverysystemforbraintumortreatment AT zhenhuayu novelnanodrugdeliverysystemforbraintumortreatment AT tingxu novelnanodrugdeliverysystemforbraintumortreatment AT liuyouwang novelnanodrugdeliverysystemforbraintumortreatment AT nanxinmeng novelnanodrugdeliverysystemforbraintumortreatment AT huaweijin novelnanodrugdeliverysystemforbraintumortreatment AT bingzhexu novelnanodrugdeliverysystemforbraintumortreatment |