Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic disease...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2017-11-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-430.pdf |
| _version_ | 1828422054470221824 |
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| author | Eugene Han Yong-ho Lee |
| author_facet | Eugene Han Yong-ho Lee |
| author_sort | Eugene Han |
| collection | DOAJ |
| description | As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged. |
| first_indexed | 2024-12-10T15:42:15Z |
| format | Article |
| id | doaj.art-92c2d826f6ba4a7297a279825abfa8b8 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-10T15:42:15Z |
| publishDate | 2017-11-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-92c2d826f6ba4a7297a279825abfa8b82022-12-22T01:43:04ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872017-11-0141643043710.4093/dmj.2017.41.6.430Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal DiseasesEugene Han0Yong-ho Lee1Division of Endocrinology and Metabolism, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.Graduate School, Yonsei University College of Medicine, Seoul, Korea.As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-430.pdfArrhythmias, cardiacAtherosclerosisDiabetes mellitusHypertensionInsulin resistanceMetabolismNon-alcoholic fatty liver diseaseObesityRenal insufficiencyStroke |
| spellingShingle | Eugene Han Yong-ho Lee Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases Diabetes & Metabolism Journal Arrhythmias, cardiac Atherosclerosis Diabetes mellitus Hypertension Insulin resistance Metabolism Non-alcoholic fatty liver disease Obesity Renal insufficiency Stroke |
| title | Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases |
| title_full | Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases |
| title_fullStr | Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases |
| title_full_unstemmed | Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases |
| title_short | Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases |
| title_sort | non alcoholic fatty liver disease the emerging burden in cardiometabolic and renal diseases |
| topic | Arrhythmias, cardiac Atherosclerosis Diabetes mellitus Hypertension Insulin resistance Metabolism Non-alcoholic fatty liver disease Obesity Renal insufficiency Stroke |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-430.pdf |
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