LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC
Aim. Study the changes in the composition of animals large intestine microbiocenosis and molecular-biochemical parameters of blood plasma and colonocytes in experimental gentamicin dysbiosis, possibility of correction using probiotic. Materials and methods. Drug dysbiosis was simulated by administra...
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| Format: | Article |
| Language: | Russian |
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Central Research Institute for Epidemiology
2018-08-01
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| Series: | Журнал микробиологии, эпидемиологии и иммунобиологии |
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| Online Access: | https://microbiol.elpub.ru/jour/article/view/283 |
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| author | A. V. Shevchenko O. A. Medvedeva A. Yu. Mukhina V. A. Korolev P. V. Kalutsky |
| author_facet | A. V. Shevchenko O. A. Medvedeva A. Yu. Mukhina V. A. Korolev P. V. Kalutsky |
| author_sort | A. V. Shevchenko |
| collection | DOAJ |
| description | Aim. Study the changes in the composition of animals large intestine microbiocenosis and molecular-biochemical parameters of blood plasma and colonocytes in experimental gentamicin dysbiosis, possibility of correction using probiotic. Materials and methods. Drug dysbiosis was simulated by administration of gentamicin intraperitoneally and with correction aim injected probiotic. Quantitative and qualitative study of mucous microflora of the mice large intestine was performed by bacteriological method. The state of lipid peroxidation system was judged about by content of acylhydroperoxide and malonic dialdehyde, antioxidant protection system - by catalase and superoxide dismutase. Results. As a result of the study, a change in the composition of the intestinal microflora, a decrease in the enzymatic activity of antioxidant defense system in blood plasma and colonocytes, an increase in the content of lipid peroxidation products in blood plasma and colonocytes were recorded. The corrective effect of RioFlora Immuno Neo probiotic regarding the restoration of the intestine normobiocenosis and the molecular-biochemical parameters of animal colonocytes was noted. Conclusion. The use of the probiotic led to the restoration of microbial equilibrium in the intestinal microbiocenosis, and also had a positive effect on the superoxide dismutase activity of colonocytes, stabilization of the malonic dialdehyde content in the colon tissue. |
| first_indexed | 2024-04-13T02:41:26Z |
| format | Article |
| id | doaj.art-92c2df680ce2440aad92c7c5f0e53cbc |
| institution | Directory Open Access Journal |
| issn | 0372-9311 2686-7613 |
| language | Russian |
| last_indexed | 2024-04-13T02:41:26Z |
| publishDate | 2018-08-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Журнал микробиологии, эпидемиологии и иммунобиологии |
| spelling | doaj.art-92c2df680ce2440aad92c7c5f0e53cbc2022-12-22T03:06:11ZrusCentral Research Institute for EpidemiologyЖурнал микробиологии, эпидемиологии и иммунобиологии0372-93112686-76132018-08-0104273310.36233/0372-9311-2018-4-27-33283LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTICA. V. Shevchenko0O. A. Medvedeva1A. Yu. Mukhina2V. A. Korolev3P. V. Kalutsky4Kursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityKursk State Medical UniversityAim. Study the changes in the composition of animals large intestine microbiocenosis and molecular-biochemical parameters of blood plasma and colonocytes in experimental gentamicin dysbiosis, possibility of correction using probiotic. Materials and methods. Drug dysbiosis was simulated by administration of gentamicin intraperitoneally and with correction aim injected probiotic. Quantitative and qualitative study of mucous microflora of the mice large intestine was performed by bacteriological method. The state of lipid peroxidation system was judged about by content of acylhydroperoxide and malonic dialdehyde, antioxidant protection system - by catalase and superoxide dismutase. Results. As a result of the study, a change in the composition of the intestinal microflora, a decrease in the enzymatic activity of antioxidant defense system in blood plasma and colonocytes, an increase in the content of lipid peroxidation products in blood plasma and colonocytes were recorded. The corrective effect of RioFlora Immuno Neo probiotic regarding the restoration of the intestine normobiocenosis and the molecular-biochemical parameters of animal colonocytes was noted. Conclusion. The use of the probiotic led to the restoration of microbial equilibrium in the intestinal microbiocenosis, and also had a positive effect on the superoxide dismutase activity of colonocytes, stabilization of the malonic dialdehyde content in the colon tissue.https://microbiol.elpub.ru/jour/article/view/283large intestine mucous microfloradysbiosisantioxidant systemrioflora immuno neo |
| spellingShingle | A. V. Shevchenko O. A. Medvedeva A. Yu. Mukhina V. A. Korolev P. V. Kalutsky LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC Журнал микробиологии, эпидемиологии и иммунобиологии large intestine mucous microflora dysbiosis antioxidant system rioflora immuno neo |
| title | LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC |
| title_full | LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC |
| title_fullStr | LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC |
| title_full_unstemmed | LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC |
| title_short | LARGE INTESTINE NORMOBIOCENOSIS AND PROOXIDANT-ANTIOXIDANT BALANCE OF COLONOCYTES, BLOOD PLASMA IN EXPERIMENTAL DISBIOOSIS AND USAGE OF RIOFLORA IMMUNO NEO PROBIOTIC |
| title_sort | large intestine normobiocenosis and prooxidant antioxidant balance of colonocytes blood plasma in experimental disbioosis and usage of rioflora immuno neo probiotic |
| topic | large intestine mucous microflora dysbiosis antioxidant system rioflora immuno neo |
| url | https://microbiol.elpub.ru/jour/article/view/283 |
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