The molecular mechanism of Gorham syndrome: an update
Gorham syndrome, also known as “vanishing osteopathy” and “invasive hemangiomatosis,” is a rare clinical syndrome whose etiology is unknown and can invade the whole-body skeleton. At present, more than 300 cases have been reported at home and abroad, usually manifesting as spontaneous chronic osteol...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165091/full |
| _version_ | 1827953695696879616 |
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| author | Juqin Xiang Weiyang Zhong |
| author_facet | Juqin Xiang Weiyang Zhong |
| author_sort | Juqin Xiang |
| collection | DOAJ |
| description | Gorham syndrome, also known as “vanishing osteopathy” and “invasive hemangiomatosis,” is a rare clinical syndrome whose etiology is unknown and can invade the whole-body skeleton. At present, more than 300 cases have been reported at home and abroad, usually manifesting as spontaneous chronic osteolysis with no periosteal reaction at the lysis site and occult onset, often with fractures, scoliosis, chylothorax, etc. When waiting for medical treatment, the condition is serious, and the prognosis is poor. At present, there is no effective treatment. The main pathological manifestations of Gorham syndrome are the non-neoplastic abnormal proliferation of lymphatic vessels or blood vessels and osteolysis caused by osteoclast proliferation or increased activity. At present, there is no unified conclusion regarding Gorham syndrome’s pathogenesis. This paper starts with the two most studied osteolysis methods at present, osteoclast osteolysis and osteolysis caused by vascular and lymphatic proliferation and summarizes the corresponding most possible molecular mechanisms in recent years to provide more ideas for Gorham syndrome treatment. |
| first_indexed | 2024-04-09T14:18:38Z |
| format | Article |
| id | doaj.art-92c8d56afa16467c8cc7416618d18b9f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T14:18:38Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-92c8d56afa16467c8cc7416618d18b9f2023-05-05T05:47:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11650911165091The molecular mechanism of Gorham syndrome: an updateJuqin Xiang0Weiyang Zhong1Chongqing Medical University, Chongqing, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaGorham syndrome, also known as “vanishing osteopathy” and “invasive hemangiomatosis,” is a rare clinical syndrome whose etiology is unknown and can invade the whole-body skeleton. At present, more than 300 cases have been reported at home and abroad, usually manifesting as spontaneous chronic osteolysis with no periosteal reaction at the lysis site and occult onset, often with fractures, scoliosis, chylothorax, etc. When waiting for medical treatment, the condition is serious, and the prognosis is poor. At present, there is no effective treatment. The main pathological manifestations of Gorham syndrome are the non-neoplastic abnormal proliferation of lymphatic vessels or blood vessels and osteolysis caused by osteoclast proliferation or increased activity. At present, there is no unified conclusion regarding Gorham syndrome’s pathogenesis. This paper starts with the two most studied osteolysis methods at present, osteoclast osteolysis and osteolysis caused by vascular and lymphatic proliferation and summarizes the corresponding most possible molecular mechanisms in recent years to provide more ideas for Gorham syndrome treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165091/fullGorham syndromemolecular mechanismlymphoid proliferationvascular proliferationosteolysis treatment |
| spellingShingle | Juqin Xiang Weiyang Zhong The molecular mechanism of Gorham syndrome: an update Frontiers in Immunology Gorham syndrome molecular mechanism lymphoid proliferation vascular proliferation osteolysis treatment |
| title | The molecular mechanism of Gorham syndrome: an update |
| title_full | The molecular mechanism of Gorham syndrome: an update |
| title_fullStr | The molecular mechanism of Gorham syndrome: an update |
| title_full_unstemmed | The molecular mechanism of Gorham syndrome: an update |
| title_short | The molecular mechanism of Gorham syndrome: an update |
| title_sort | molecular mechanism of gorham syndrome an update |
| topic | Gorham syndrome molecular mechanism lymphoid proliferation vascular proliferation osteolysis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165091/full |
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