Escape from senescence: revisiting cancer therapeutic strategies
Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may ben...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | Molecular & Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1080/23723556.2022.2030158 |
| _version_ | 1797677091141976064 |
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| author | Christos P. Zampetidis Argyris Papantonis Vassilis G. Gorgoulis |
| author_facet | Christos P. Zampetidis Argyris Papantonis Vassilis G. Gorgoulis |
| author_sort | Christos P. Zampetidis |
| collection | DOAJ |
| description | Although senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents. |
| first_indexed | 2024-03-11T22:40:01Z |
| format | Article |
| id | doaj.art-92c933d9b1af445fbbe58bcfae4aa5b3 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:01Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-92c933d9b1af445fbbe58bcfae4aa5b32023-09-22T09:19:44ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562022-12-019110.1080/23723556.2022.20301582030158Escape from senescence: revisiting cancer therapeutic strategiesChristos P. Zampetidis0Argyris Papantonis1Vassilis G. Gorgoulis2National Kapodistrian University of AthensUniversity Medical Center GöttingenNational Kapodistrian University of AthensAlthough senescence has been considered as an irreversible cell arrest state, accumulating evidence challenge this view. Consequently, senescence appears as an imperfect barrier to impede cancer progression, constituting a step prior to disease relapse. Therefore, cancer treatment strategies may benefit if revisited to include senolytic agents.http://dx.doi.org/10.1080/23723556.2022.2030158 |
| spellingShingle | Christos P. Zampetidis Argyris Papantonis Vassilis G. Gorgoulis Escape from senescence: revisiting cancer therapeutic strategies Molecular & Cellular Oncology |
| title | Escape from senescence: revisiting cancer therapeutic strategies |
| title_full | Escape from senescence: revisiting cancer therapeutic strategies |
| title_fullStr | Escape from senescence: revisiting cancer therapeutic strategies |
| title_full_unstemmed | Escape from senescence: revisiting cancer therapeutic strategies |
| title_short | Escape from senescence: revisiting cancer therapeutic strategies |
| title_sort | escape from senescence revisiting cancer therapeutic strategies |
| url | http://dx.doi.org/10.1080/23723556.2022.2030158 |
| work_keys_str_mv | AT christospzampetidis escapefromsenescencerevisitingcancertherapeuticstrategies AT argyrispapantonis escapefromsenescencerevisitingcancertherapeuticstrategies AT vassilisggorgoulis escapefromsenescencerevisitingcancertherapeuticstrategies |