High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease
ObjectivesThis study aimed to primarily examine the association between memory deficit and increased fall risk, second, explore the underlying neuroanatomical linkage of this association in the elderly with aMCI and mild AD.MethodsIn this cross-sectional study, a total of 103 older adults were inclu...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.896437/full |
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| author | Shuyun Huang Shuyun Huang Xinhan Zhou Yajing Liu Jiali Luo Zeping Lv Pan Shang Weiping Zhang Biqing Lin Qiulan Huang YanYun Feng Wei Wang Shuai Tao Yukai Wang Chengguo Zhang Lushi Chen Lin Shi Lin Shi Yishan Luo Vincent C. T. Mok Suyue Pan Haiqun Xie |
| author_facet | Shuyun Huang Shuyun Huang Xinhan Zhou Yajing Liu Jiali Luo Zeping Lv Pan Shang Weiping Zhang Biqing Lin Qiulan Huang YanYun Feng Wei Wang Shuai Tao Yukai Wang Chengguo Zhang Lushi Chen Lin Shi Lin Shi Yishan Luo Vincent C. T. Mok Suyue Pan Haiqun Xie |
| author_sort | Shuyun Huang |
| collection | DOAJ |
| description | ObjectivesThis study aimed to primarily examine the association between memory deficit and increased fall risk, second, explore the underlying neuroanatomical linkage of this association in the elderly with aMCI and mild AD.MethodsIn this cross-sectional study, a total of 103 older adults were included (55 cognitively normal, CN; 48 cognitive impairment, CI, elderly with aMCI, and mild AD). Memory was assessed by the Auditory Verbal Learning Test (AVLT). Fall risk was evaluated by the Timed Up and Go (TUG) Test, heel strike angles, and stride speed, which were collected by an inertial-sensor-based wearable instrument (the JiBuEn™ gait analysis system). Brain volumes were full-automatic segmented and quantified using AccuBrain® v1.2 from three-dimensional T1-weighted (3D T1W) MR images. Multivariable regression analysis was used to examine the extent of the association between memory deficit and fall risk, the association of brain volumes with memory, and fall risk. Age, sex, education, BMI, and HAMD scores were adjusted. Sensitivity analysis was conducted.ResultsCompared to CN, participants with aMCI and mild AD had poorer cognitive performance (p < 0.001), longer TUG time (p = 0.018), and smaller hippocampus and medial temporal volumes (p = 0.037 and 0.029). In the CI group, compared to good short delayed memory (SDM) performance (AVLT > 5), the elderly with bad SDM performance (AVLT ≤ 3) had longer TUG time, smaller heel strike angles, and slower stride speed. Multivariable regression analysis showed that elderly with poor memory had higher fall risk than relative good memory performance among cognitive impairment elderly. The TUG time increased by 2.1 s, 95% CI, 0.54∼3.67; left heel strike angle reduced by 3.22°, 95% CI, −6.05 to −0.39; and stride speed reduced by 0.09 m/s, 95% CI, −0.19 to −0.00 for the poor memory elderly among the CI group, but not found the association in CN group. In addition, serious medial temporal atrophy (MTA), small volumes of the frontal lobe and occipital lobe were associated with long TUG time and small heel strike angles; small volumes of the temporal lobe, frontal lobe, and parietal lobe were associated with slow stride speed.ConclusionOur findings suggested that memory deficit was associated with increased fall risk in the elderly with aMCI and mild AD. The association might be mediated by the atrophy of medial temporal, frontal, and parietal lobes. Additionally, increased fall risk, tested by TUG time, heel stride angles, and stride speed, might be objective and convenient kinematics markers for dynamic monitoring of both memory function and fall risk. |
| first_indexed | 2024-04-13T21:19:36Z |
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| id | doaj.art-92c9b07b8c50415f8c6e3df2f55b5da9 |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T21:19:36Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-92c9b07b8c50415f8c6e3df2f55b5da92022-12-22T02:29:32ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.896437896437High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s DiseaseShuyun Huang0Shuyun Huang1Xinhan Zhou2Yajing Liu3Jiali Luo4Zeping Lv5Pan Shang6Weiping Zhang7Biqing Lin8Qiulan Huang9YanYun Feng10Wei Wang11Shuai Tao12Yukai Wang13Chengguo Zhang14Lushi Chen15Lin Shi16Lin Shi17Yishan Luo18Vincent C. T. Mok19Suyue Pan20Haiqun Xie21Department of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Imaging, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaNational Research Center for Rehabilitation Technical Aids, Rehabilitation Hospital, Beijing, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Imaging, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Imaging, First People’s Hospital of Foshan, Foshan, ChinaDalian Key Laboratory of Smart Medical and Health, Dalian University, Dalian, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaBrainNow Research Institute, Shenzhen, ChinaBrainNow Research Institute, Shenzhen, ChinaDivision of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, ChinaDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDepartment of Neurology, First People’s Hospital of Foshan, Foshan, ChinaObjectivesThis study aimed to primarily examine the association between memory deficit and increased fall risk, second, explore the underlying neuroanatomical linkage of this association in the elderly with aMCI and mild AD.MethodsIn this cross-sectional study, a total of 103 older adults were included (55 cognitively normal, CN; 48 cognitive impairment, CI, elderly with aMCI, and mild AD). Memory was assessed by the Auditory Verbal Learning Test (AVLT). Fall risk was evaluated by the Timed Up and Go (TUG) Test, heel strike angles, and stride speed, which were collected by an inertial-sensor-based wearable instrument (the JiBuEn™ gait analysis system). Brain volumes were full-automatic segmented and quantified using AccuBrain® v1.2 from three-dimensional T1-weighted (3D T1W) MR images. Multivariable regression analysis was used to examine the extent of the association between memory deficit and fall risk, the association of brain volumes with memory, and fall risk. Age, sex, education, BMI, and HAMD scores were adjusted. Sensitivity analysis was conducted.ResultsCompared to CN, participants with aMCI and mild AD had poorer cognitive performance (p < 0.001), longer TUG time (p = 0.018), and smaller hippocampus and medial temporal volumes (p = 0.037 and 0.029). In the CI group, compared to good short delayed memory (SDM) performance (AVLT > 5), the elderly with bad SDM performance (AVLT ≤ 3) had longer TUG time, smaller heel strike angles, and slower stride speed. Multivariable regression analysis showed that elderly with poor memory had higher fall risk than relative good memory performance among cognitive impairment elderly. The TUG time increased by 2.1 s, 95% CI, 0.54∼3.67; left heel strike angle reduced by 3.22°, 95% CI, −6.05 to −0.39; and stride speed reduced by 0.09 m/s, 95% CI, −0.19 to −0.00 for the poor memory elderly among the CI group, but not found the association in CN group. In addition, serious medial temporal atrophy (MTA), small volumes of the frontal lobe and occipital lobe were associated with long TUG time and small heel strike angles; small volumes of the temporal lobe, frontal lobe, and parietal lobe were associated with slow stride speed.ConclusionOur findings suggested that memory deficit was associated with increased fall risk in the elderly with aMCI and mild AD. The association might be mediated by the atrophy of medial temporal, frontal, and parietal lobes. Additionally, increased fall risk, tested by TUG time, heel stride angles, and stride speed, might be objective and convenient kinematics markers for dynamic monitoring of both memory function and fall risk.https://www.frontiersin.org/articles/10.3389/fnins.2022.896437/fullfall riskmemory deficitmedial temporal lobe atrophyamnestic mild cognitive impairmentmild Alzheimer’s disease |
| spellingShingle | Shuyun Huang Shuyun Huang Xinhan Zhou Yajing Liu Jiali Luo Zeping Lv Pan Shang Weiping Zhang Biqing Lin Qiulan Huang YanYun Feng Wei Wang Shuai Tao Yukai Wang Chengguo Zhang Lushi Chen Lin Shi Lin Shi Yishan Luo Vincent C. T. Mok Suyue Pan Haiqun Xie High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease Frontiers in Neuroscience fall risk memory deficit medial temporal lobe atrophy amnestic mild cognitive impairment mild Alzheimer’s disease |
| title | High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease |
| title_full | High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease |
| title_fullStr | High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease |
| title_full_unstemmed | High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease |
| title_short | High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease |
| title_sort | high fall risk associated with memory deficit and brain lobes atrophy among elderly with amnestic mild cognitive impairment and mild alzheimer s disease |
| topic | fall risk memory deficit medial temporal lobe atrophy amnestic mild cognitive impairment mild Alzheimer’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.896437/full |
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