Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches
Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose.
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-02883-z |
| _version_ | 1818992770137718784 |
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| author | Xiaonan Liu Jian Cheng Guanghui Zhang Wentao Ding Lijin Duan Jing Yang Ling Kui Xiaozhi Cheng Jiangxing Ruan Wei Fan Junwen Chen Guangqiang Long Yan Zhao Jing Cai Wen Wang Yanhe Ma Yang Dong Shengchao Yang Huifeng Jiang |
| author_facet | Xiaonan Liu Jian Cheng Guanghui Zhang Wentao Ding Lijin Duan Jing Yang Ling Kui Xiaozhi Cheng Jiangxing Ruan Wei Fan Junwen Chen Guangqiang Long Yan Zhao Jing Cai Wen Wang Yanhe Ma Yang Dong Shengchao Yang Huifeng Jiang |
| author_sort | Xiaonan Liu |
| collection | DOAJ |
| description | Breviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose. |
| first_indexed | 2024-12-20T20:31:26Z |
| format | Article |
| id | doaj.art-92caa47494d0490abeaced8635892682 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:31:26Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-92caa47494d0490abeaced86358926822022-12-21T19:27:21ZengNature PortfolioNature Communications2041-17232018-01-019111010.1038/s41467-018-02883-zEngineering yeast for the production of breviscapine by genomic analysis and synthetic biology approachesXiaonan Liu0Jian Cheng1Guanghui Zhang2Wentao Ding3Lijin Duan4Jing Yang5Ling Kui6Xiaozhi Cheng7Jiangxing Ruan8Wei Fan9Junwen Chen10Guangqiang Long11Yan Zhao12Jing Cai13Wen Wang14Yanhe Ma15Yang Dong16Shengchao Yang17Huifeng Jiang18Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityUniversity of Chinese Academy of SciencesKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of MacauState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityState Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan, The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural UniversityKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of SciencesBreviscapine is the flavonoid extract from medical plant Erigeron breviscapus for the treatment of cardio- and cerebrovascular disease. Here, the authors identify the key enzymes of the biosynthetic pathway from the plant genome and engineer yeast to produce breviscapine from glucose.https://doi.org/10.1038/s41467-018-02883-z |
| spellingShingle | Xiaonan Liu Jian Cheng Guanghui Zhang Wentao Ding Lijin Duan Jing Yang Ling Kui Xiaozhi Cheng Jiangxing Ruan Wei Fan Junwen Chen Guangqiang Long Yan Zhao Jing Cai Wen Wang Yanhe Ma Yang Dong Shengchao Yang Huifeng Jiang Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches Nature Communications |
| title | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_full | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_fullStr | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_full_unstemmed | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_short | Engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| title_sort | engineering yeast for the production of breviscapine by genomic analysis and synthetic biology approaches |
| url | https://doi.org/10.1038/s41467-018-02883-z |
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