Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report
Abid M Sadiq,1,2 Jamil M Suleiman,1 Hassan S Vuai,1 Adnan M Sadiq,2,3 Elifuraha W Mkwizu1,2,4 1Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; 2Kilimanjaro Christian Medical University College, Moshi, Tanzania; 3Department of Radiology, Kilimanjaro Christian M...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-08-01
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| Series: | International Medical Case Reports Journal |
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| Online Access: | https://www.dovepress.com/lower-gastrointestinal-involvement-in-multiple-myeloma-a-case-report-peer-reviewed-article-IMCRJ |
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| author | Sadiq AM Suleiman JM Vuai HS Sadiq AM Mkwizu EW |
| author_facet | Sadiq AM Suleiman JM Vuai HS Sadiq AM Mkwizu EW |
| author_sort | Sadiq AM |
| collection | DOAJ |
| description | Abid M Sadiq,1,2 Jamil M Suleiman,1 Hassan S Vuai,1 Adnan M Sadiq,2,3 Elifuraha W Mkwizu1,2,4 1Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; 2Kilimanjaro Christian Medical University College, Moshi, Tanzania; 3Department of Radiology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; 4Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, TanzaniaCorrespondence: Abid M SadiqDepartment of Internal Medicine, Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, TanzaniaEmail abid.physician@gmail.comAbstract: Multiple myeloma (MM) commonly presents with anemia and bone pain. Besides bone marrow involvement, MM has a tendency to involve other organs with gastrointestinal (GI) tract, especially lower GI tract involvement being uncommon. Our case shows an elderly male with anemia due to suspected GI malignancy. Investigations revealed anemia, thrombocytopenia, positive stool occult blood and inconclusive diagnostic endoscopic findings. An elevated serum total protein, serum calcium and serum creatinine gave rise to the suspicion of MM which was later supported by the fulfilment of the CRAB criteria, expressed as hypercalcemia, renal failure, anemia and lytic lesions on skull X-ray. The relationship between multiple myeloma and GI bleeding is rare and indicates extramedullary disease which is a sign of poor prognosis. Early detection may alter the prognostic course of MM.Keywords: multiple myeloma, anemia, gastrointestinal, bleeding |
| first_indexed | 2024-12-19T00:21:44Z |
| format | Article |
| id | doaj.art-92ceb1db87754a709023718b334bee5a |
| institution | Directory Open Access Journal |
| issn | 1179-142X |
| language | English |
| last_indexed | 2024-12-19T00:21:44Z |
| publishDate | 2020-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Medical Case Reports Journal |
| spelling | doaj.art-92ceb1db87754a709023718b334bee5a2022-12-21T20:45:30ZengDove Medical PressInternational Medical Case Reports Journal1179-142X2020-08-01Volume 1335335756468Lower Gastrointestinal Involvement in Multiple Myeloma: A Case ReportSadiq AMSuleiman JMVuai HSSadiq AMMkwizu EWAbid M Sadiq,1,2 Jamil M Suleiman,1 Hassan S Vuai,1 Adnan M Sadiq,2,3 Elifuraha W Mkwizu1,2,4 1Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; 2Kilimanjaro Christian Medical University College, Moshi, Tanzania; 3Department of Radiology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; 4Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, TanzaniaCorrespondence: Abid M SadiqDepartment of Internal Medicine, Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, TanzaniaEmail abid.physician@gmail.comAbstract: Multiple myeloma (MM) commonly presents with anemia and bone pain. Besides bone marrow involvement, MM has a tendency to involve other organs with gastrointestinal (GI) tract, especially lower GI tract involvement being uncommon. Our case shows an elderly male with anemia due to suspected GI malignancy. Investigations revealed anemia, thrombocytopenia, positive stool occult blood and inconclusive diagnostic endoscopic findings. An elevated serum total protein, serum calcium and serum creatinine gave rise to the suspicion of MM which was later supported by the fulfilment of the CRAB criteria, expressed as hypercalcemia, renal failure, anemia and lytic lesions on skull X-ray. The relationship between multiple myeloma and GI bleeding is rare and indicates extramedullary disease which is a sign of poor prognosis. Early detection may alter the prognostic course of MM.Keywords: multiple myeloma, anemia, gastrointestinal, bleedinghttps://www.dovepress.com/lower-gastrointestinal-involvement-in-multiple-myeloma-a-case-report-peer-reviewed-article-IMCRJmultiple myelomaanemiagastrointestinalbleeding |
| spellingShingle | Sadiq AM Suleiman JM Vuai HS Sadiq AM Mkwizu EW Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report International Medical Case Reports Journal multiple myeloma anemia gastrointestinal bleeding |
| title | Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report |
| title_full | Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report |
| title_fullStr | Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report |
| title_full_unstemmed | Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report |
| title_short | Lower Gastrointestinal Involvement in Multiple Myeloma: A Case Report |
| title_sort | lower gastrointestinal involvement in multiple myeloma a case report |
| topic | multiple myeloma anemia gastrointestinal bleeding |
| url | https://www.dovepress.com/lower-gastrointestinal-involvement-in-multiple-myeloma-a-case-report-peer-reviewed-article-IMCRJ |
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