Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population
Introduction: Cardiovascular diseases (CVDs) are the leading cause of death both globally and in the United Arab Emirates (UAE). Vitamin D deficiency, obesity and diabetes mellitus (DM) are significantly prevalent in the UAE population and are considered high-risk factors for CVDs. In the meantime,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Hamdan Medical Journal |
| Subjects: | |
| Online Access: | http://www.hamdanjournal.org/article.asp?issn=2227-2437;year=2023;volume=16;issue=2;spage=74;epage=78;aulast=Elmoselhi |
| _version_ | 1797775228595601408 |
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| author | Adel B Elmoselhi Zeinab Ibrahim Mohamed Ibrahim Madkour Mohamed Seif Allah |
| author_facet | Adel B Elmoselhi Zeinab Ibrahim Mohamed Ibrahim Madkour Mohamed Seif Allah |
| author_sort | Adel B Elmoselhi |
| collection | DOAJ |
| description | Introduction: Cardiovascular diseases (CVDs) are the leading cause of death both globally and in the United Arab Emirates (UAE). Vitamin D deficiency, obesity and diabetes mellitus (DM) are significantly prevalent in the UAE population and are considered high-risk factors for CVDs. In the meantime, arterial stiffness has been reported to be an independent predictor of CVDs with a strong association with vascular inflammatory reactions. Aims and Objectives: Identify and analyze specific inflammatory biomarkers associated with arterial stiffness in order to enhance the detection and prevention of cardiovascular diseases (CVDs) among high-risk patients. Materials and Methods: We have recruited 23 middle-aged Emiratis with the following criteria: 11 individuals as controls (Vitamin D level >20 ng and body mass index [BMI] <30), 9 patients with Vitamin D deficiency (Vitamin D level ≤20 ng) and obese (BMI ≥30) and 3 patients with Vitamin D deficiency (Vitamin D level ≤20 ng), obese (BMI ≥30) and previously diagnosed with type 2 DM. Several inflammatory biomarkers were measured in the plasma samples using Luminex Human Cytokine Pre-mixed Kit. Results: Arterial stiffness was measured using pulse-wave velocity (PWV). The PWV relative to age was significantly higher in both patient groups compared to the control group. Furthermore, there is a significant increase in the plasma protein levels of interleukin (IL)-6 cytokine (P = 0.0229) and tumor necrosis factor-alpha (TNF-α) cytokine (P = 0.0258) in Vitamin D deficiency, obese and diabetic patients compared to the control group. The rest of the inflammatory markers did not show statistically significant changes in the plasma levels. Conclusion: Our findings reveal that individuals with Vitamin D deficiency, obesity, and DM exhibit elevated plasma protein levels of IL-6 and TNF-α cytokines when compared to the control group and individuals with only Vitamin D deficiency or obesity. These increased levels of cytokines are closely associated with arterial stiffness, highlighting their potential as biomarkers for early detection of vascular damage in high-risk patients, thereby aiding in the prevention of CVDs. However, further research with a larger cohort is warranted to validate and explore these significant pathways and biomarkers in greater detail. |
| first_indexed | 2024-03-12T22:32:43Z |
| format | Article |
| id | doaj.art-92cebfedb33f4ba397e5adf69e0022e7 |
| institution | Directory Open Access Journal |
| issn | 2227-2437 2227-247X |
| language | English |
| last_indexed | 2024-03-12T22:32:43Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Hamdan Medical Journal |
| spelling | doaj.art-92cebfedb33f4ba397e5adf69e0022e72023-07-21T14:44:41ZengWolters Kluwer Medknow PublicationsHamdan Medical Journal2227-24372227-247X2023-01-01162747810.4103/hmj.hmj_89_22Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati populationAdel B ElmoselhiZeinab IbrahimMohamed Ibrahim MadkourMohamed Seif AllahIntroduction: Cardiovascular diseases (CVDs) are the leading cause of death both globally and in the United Arab Emirates (UAE). Vitamin D deficiency, obesity and diabetes mellitus (DM) are significantly prevalent in the UAE population and are considered high-risk factors for CVDs. In the meantime, arterial stiffness has been reported to be an independent predictor of CVDs with a strong association with vascular inflammatory reactions. Aims and Objectives: Identify and analyze specific inflammatory biomarkers associated with arterial stiffness in order to enhance the detection and prevention of cardiovascular diseases (CVDs) among high-risk patients. Materials and Methods: We have recruited 23 middle-aged Emiratis with the following criteria: 11 individuals as controls (Vitamin D level >20 ng and body mass index [BMI] <30), 9 patients with Vitamin D deficiency (Vitamin D level ≤20 ng) and obese (BMI ≥30) and 3 patients with Vitamin D deficiency (Vitamin D level ≤20 ng), obese (BMI ≥30) and previously diagnosed with type 2 DM. Several inflammatory biomarkers were measured in the plasma samples using Luminex Human Cytokine Pre-mixed Kit. Results: Arterial stiffness was measured using pulse-wave velocity (PWV). The PWV relative to age was significantly higher in both patient groups compared to the control group. Furthermore, there is a significant increase in the plasma protein levels of interleukin (IL)-6 cytokine (P = 0.0229) and tumor necrosis factor-alpha (TNF-α) cytokine (P = 0.0258) in Vitamin D deficiency, obese and diabetic patients compared to the control group. The rest of the inflammatory markers did not show statistically significant changes in the plasma levels. Conclusion: Our findings reveal that individuals with Vitamin D deficiency, obesity, and DM exhibit elevated plasma protein levels of IL-6 and TNF-α cytokines when compared to the control group and individuals with only Vitamin D deficiency or obesity. These increased levels of cytokines are closely associated with arterial stiffness, highlighting their potential as biomarkers for early detection of vascular damage in high-risk patients, thereby aiding in the prevention of CVDs. However, further research with a larger cohort is warranted to validate and explore these significant pathways and biomarkers in greater detail.http://www.hamdanjournal.org/article.asp?issn=2227-2437;year=2023;volume=16;issue=2;spage=74;epage=78;aulast=Elmoselhiarterial stiffnesscytokinesdiabetes mellitusinflammatory markersobesityvitamin d deficiency |
| spellingShingle | Adel B Elmoselhi Zeinab Ibrahim Mohamed Ibrahim Madkour Mohamed Seif Allah Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population Hamdan Medical Journal arterial stiffness cytokines diabetes mellitus inflammatory markers obesity vitamin d deficiency |
| title | Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population |
| title_full | Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population |
| title_fullStr | Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population |
| title_full_unstemmed | Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population |
| title_short | Interleukin-6 and tumour necrosis factor-alpha inflammatory markers association with arterial stiffness in Vitamin D3 deficiency, obese and diabetic emirati population |
| title_sort | interleukin 6 and tumour necrosis factor alpha inflammatory markers association with arterial stiffness in vitamin d3 deficiency obese and diabetic emirati population |
| topic | arterial stiffness cytokines diabetes mellitus inflammatory markers obesity vitamin d deficiency |
| url | http://www.hamdanjournal.org/article.asp?issn=2227-2437;year=2023;volume=16;issue=2;spage=74;epage=78;aulast=Elmoselhi |
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