Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats
Abstract We aimed to evaluate how high-fat diet consumption can interfere with rat reproductive performance and fetal development. High-fat diet (HFD) was initiated in 30-day-old rats, distributed into two groups (n=7 animals/group): Rats receiving a standard diet and rats receiving HFD. At adulthoo...
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Academia Brasileira de Ciências
2023-12-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500601&lng=en&tlng=en |
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| author | MARIA EDUARDA P. GOMES LUIGI M.J. DIDOMIZIO YURI K. SINZATO VERÔNYCA G. PAULA MAYSA R. SOUZA FRANCIANE Q. GALLEGO VINÍCIUS S. BARCO GUSTAVO T. VOLPATO DÉBORA CRISTINA DAMASCENO |
| author_facet | MARIA EDUARDA P. GOMES LUIGI M.J. DIDOMIZIO YURI K. SINZATO VERÔNYCA G. PAULA MAYSA R. SOUZA FRANCIANE Q. GALLEGO VINÍCIUS S. BARCO GUSTAVO T. VOLPATO DÉBORA CRISTINA DAMASCENO |
| author_sort | MARIA EDUARDA P. GOMES |
| collection | DOAJ |
| description | Abstract We aimed to evaluate how high-fat diet consumption can interfere with rat reproductive performance and fetal development. High-fat diet (HFD) was initiated in 30-day-old rats, distributed into two groups (n=7 animals/group): Rats receiving a standard diet and rats receiving HFD. At adulthood, the rats were mated, and on day 21 of pregnancy, the females were anesthetized, decapitated, and submitted to laparotomy to obtain visceral and periovarian adipose tissue. The uterine horns were exposed for analysis of maternal reproductive performance. The fetuses and placentas were weighed and analyzed. Pearson’s correlation test was used, and p<0.05 was considered significant. There was a significant positive correlation (HFD consumption x increased periovarian fat) and a negative correlation with the implantation, live fetus numbers and lower litter weight. Furthermore, the increased relative weight of periuterine fat was related to the lower number of live fetuses and litter weight. Regarding the fetal weight classification, there was a negative correlation between the relative weight of periovarian fat and the percentage of fetuses appropriate for gestational age and large for gestational age. Therefore, our findings show that HFD maternal intake negatively influenced on reproductive performance and fetal growth. |
| first_indexed | 2024-03-09T02:53:16Z |
| format | Article |
| id | doaj.art-92cfbe0dc4f94816b51a929d999afe9c |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-03-09T02:53:16Z |
| publishDate | 2023-12-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-92cfbe0dc4f94816b51a929d999afe9c2023-12-05T07:58:44ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902023-12-0195suppl 210.1590/0001-3765202320230079Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in ratsMARIA EDUARDA P. GOMEShttps://orcid.org/0000-0003-0864-8576LUIGI M.J. DIDOMIZIOhttps://orcid.org/0000-0002-6990-1515YURI K. SINZATOhttps://orcid.org/0000-0002-2973-1099VERÔNYCA G. PAULAhttps://orcid.org/0000-0002-1590-9781MAYSA R. SOUZAhttps://orcid.org/0000-0002-2144-5004FRANCIANE Q. GALLEGOhttps://orcid.org/0000-0002-6081-7763VINÍCIUS S. BARCOhttps://orcid.org/0000-0003-1759-0011GUSTAVO T. VOLPATOhttps://orcid.org/0000-0002-4753-3264DÉBORA CRISTINA DAMASCENOhttps://orcid.org/0000-0002-7003-9643Abstract We aimed to evaluate how high-fat diet consumption can interfere with rat reproductive performance and fetal development. High-fat diet (HFD) was initiated in 30-day-old rats, distributed into two groups (n=7 animals/group): Rats receiving a standard diet and rats receiving HFD. At adulthood, the rats were mated, and on day 21 of pregnancy, the females were anesthetized, decapitated, and submitted to laparotomy to obtain visceral and periovarian adipose tissue. The uterine horns were exposed for analysis of maternal reproductive performance. The fetuses and placentas were weighed and analyzed. Pearson’s correlation test was used, and p<0.05 was considered significant. There was a significant positive correlation (HFD consumption x increased periovarian fat) and a negative correlation with the implantation, live fetus numbers and lower litter weight. Furthermore, the increased relative weight of periuterine fat was related to the lower number of live fetuses and litter weight. Regarding the fetal weight classification, there was a negative correlation between the relative weight of periovarian fat and the percentage of fetuses appropriate for gestational age and large for gestational age. Therefore, our findings show that HFD maternal intake negatively influenced on reproductive performance and fetal growth.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500601&lng=en&tlng=enHigh-fat dietfetusratsreproductionpregnancy |
| spellingShingle | MARIA EDUARDA P. GOMES LUIGI M.J. DIDOMIZIO YURI K. SINZATO VERÔNYCA G. PAULA MAYSA R. SOUZA FRANCIANE Q. GALLEGO VINÍCIUS S. BARCO GUSTAVO T. VOLPATO DÉBORA CRISTINA DAMASCENO Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats Anais da Academia Brasileira de Ciências High-fat diet fetus rats reproduction pregnancy |
| title | Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats |
| title_full | Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats |
| title_fullStr | Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats |
| title_full_unstemmed | Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats |
| title_short | Influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats |
| title_sort | influence of maternal periuterine and periovarian fat on reproductive performance and fetal growth in rats |
| topic | High-fat diet fetus rats reproduction pregnancy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500601&lng=en&tlng=en |
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