Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials
Abstract Objective This systematic review and meta‐analysis aimed to assess whether preoperative administration of calcium and vitamin D prevents postoperative hypocalcemia. Data Sources A computerized search in Medline, Embase, and CENTRAL databases was performed. Review Methods Trials comparing pr...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | OTO Open |
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| Online Access: | https://doi.org/10.1002/oto2.116 |
| _version_ | 1797223042492923904 |
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| author | Mohammed Alhakami Ghassan Bin Lajdam Abdullah A. Ghaddaf Sarah Alayoubi Shaden Alhelali Mohammad Alshareef Jabir Alharbi |
| author_facet | Mohammed Alhakami Ghassan Bin Lajdam Abdullah A. Ghaddaf Sarah Alayoubi Shaden Alhelali Mohammad Alshareef Jabir Alharbi |
| author_sort | Mohammed Alhakami |
| collection | DOAJ |
| description | Abstract Objective This systematic review and meta‐analysis aimed to assess whether preoperative administration of calcium and vitamin D prevents postoperative hypocalcemia. Data Sources A computerized search in Medline, Embase, and CENTRAL databases was performed. Review Methods Trials comparing preoperative calcium and vitamin D administration with either placebo or nothing were eligible for inclusion. The primary outcomes were the occurrence of laboratory hypocalcemia, mean postoperative calcium level, and symptomatic hypocalcemia. The secondary outcomes were the development of permanent hypoparathyroidism and length of hospitalization. Continuous outcomes were represented as standardized mean difference (SMD), and dichotomous outcomes were represented as risk ratio (RR). Results Nine trials that enrolled 1079 patients were found eligible. Postoperative laboratory hypocalcemia occurred less in patients who received preoperative calcium and vitamin D, but it was not statistically significant (RR = 0.77, 95% CI: 0.60‐1.00; P = .05). Mean postoperative calcium level was significantly higher in the intervention group (SMD = 0.10, 95% CI: 0.07‐0.12; P < .00001). The number of patients with symptomatic hypocalcemia was significantly lower in the intervention group (RR = 0.54, 95% CI: 0.38‐0.76; P = .0005). There was no significant difference between the 2 groups in cases of permanent hypoparathyroidism and length of hospitalization. Conclusion Administration of calcium and vitamin D preoperatively achieves lower rates of postthyroidectomy symptomatic hypocalcemia in comparison with no intervention. |
| first_indexed | 2024-04-24T13:30:56Z |
| format | Article |
| id | doaj.art-92d08aa42dc4417ca047680b9f18e8c6 |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-04-24T13:30:56Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-92d08aa42dc4417ca047680b9f18e8c62024-04-04T09:30:28ZengWileyOTO Open2473-974X2024-01-0181n/an/a10.1002/oto2.116Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled TrialsMohammed Alhakami0Ghassan Bin Lajdam1Abdullah A. Ghaddaf2Sarah Alayoubi3Shaden Alhelali4Mohammad Alshareef5Jabir Alharbi6College of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi ArabiaCollege of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi ArabiaCollege of Medicine King Saud bin Abdulaziz University for Health Sciences Jeddah Saudi ArabiaDepartment of Otolaryngology‐Head & Neck Surgery, King Saud bin Abdulaziz University for Health Sciences King Abdulaziz Medical City Jeddah Saudi ArabiaCollage of Medicine Ibn Sina National Collage for Medical Studies Jeddah Saudi ArabiaDepartment of Otolaryngology‐Head & Neck Surgery, King Saud bin Abdulaziz University for Health Sciences King Abdulaziz Medical City Jeddah Saudi ArabiaHead & Neck and Skull Base Health Center King Abdullah Medical City Makkah Saudi ArabiaAbstract Objective This systematic review and meta‐analysis aimed to assess whether preoperative administration of calcium and vitamin D prevents postoperative hypocalcemia. Data Sources A computerized search in Medline, Embase, and CENTRAL databases was performed. Review Methods Trials comparing preoperative calcium and vitamin D administration with either placebo or nothing were eligible for inclusion. The primary outcomes were the occurrence of laboratory hypocalcemia, mean postoperative calcium level, and symptomatic hypocalcemia. The secondary outcomes were the development of permanent hypoparathyroidism and length of hospitalization. Continuous outcomes were represented as standardized mean difference (SMD), and dichotomous outcomes were represented as risk ratio (RR). Results Nine trials that enrolled 1079 patients were found eligible. Postoperative laboratory hypocalcemia occurred less in patients who received preoperative calcium and vitamin D, but it was not statistically significant (RR = 0.77, 95% CI: 0.60‐1.00; P = .05). Mean postoperative calcium level was significantly higher in the intervention group (SMD = 0.10, 95% CI: 0.07‐0.12; P < .00001). The number of patients with symptomatic hypocalcemia was significantly lower in the intervention group (RR = 0.54, 95% CI: 0.38‐0.76; P = .0005). There was no significant difference between the 2 groups in cases of permanent hypoparathyroidism and length of hospitalization. Conclusion Administration of calcium and vitamin D preoperatively achieves lower rates of postthyroidectomy symptomatic hypocalcemia in comparison with no intervention.https://doi.org/10.1002/oto2.116calciumhypocalcemiathyroid diseasethyroidectomyvitamin D |
| spellingShingle | Mohammed Alhakami Ghassan Bin Lajdam Abdullah A. Ghaddaf Sarah Alayoubi Shaden Alhelali Mohammad Alshareef Jabir Alharbi Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials OTO Open calcium hypocalcemia thyroid disease thyroidectomy vitamin D |
| title | Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials |
| title_full | Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials |
| title_fullStr | Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials |
| title_full_unstemmed | Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials |
| title_short | Preoperative Vitamin D and Calcium Administration in Patients Undergoing Thyroidectomy: A Systematic Review and Meta‐analysis of Randomized Controlled Trials |
| title_sort | preoperative vitamin d and calcium administration in patients undergoing thyroidectomy a systematic review and meta analysis of randomized controlled trials |
| topic | calcium hypocalcemia thyroid disease thyroidectomy vitamin D |
| url | https://doi.org/10.1002/oto2.116 |
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