ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release
Abstract As a kind of promising drug carriers, smart polymers have attracted much attention due to the effective and controlled drug release in target cells. Herein, a reactive oxygen species (ROS)‐responsive thioether‐containing amphiphilic hyperbranched polymer prepared from MTPA and TMPTGE (HBPMT...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-09-01
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| Series: | SmartMat |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/smm2.1092 |
| _version_ | 1828452874191896576 |
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| author | Guanchun Wang Ping Huang Lei Wang Xinliang Chen Yongfeng Zhou Wei Huang Deyue Yan |
| author_facet | Guanchun Wang Ping Huang Lei Wang Xinliang Chen Yongfeng Zhou Wei Huang Deyue Yan |
| author_sort | Guanchun Wang |
| collection | DOAJ |
| description | Abstract As a kind of promising drug carriers, smart polymers have attracted much attention due to the effective and controlled drug release in target cells. Herein, a reactive oxygen species (ROS)‐responsive thioether‐containing amphiphilic hyperbranched polymer prepared from MTPA and TMPTGE (HBPMT) is synthesized from 3‐(methylthio)propylamine (MTPA) and trimethylolpropane triglycidyl ether (TMPTGE) by the amine‐epoxy click reaction via A2 + B3 one‐pot approach. Benefiting from its inherent amphiphilic nature, HBPMT can self‐assemble into stable micelles in water. Triggered by H2O2, these micelles can be dissociated rapidly because hydrophobic thioether segments in their cores are oxidized into hydrophilic sulfoxide or sulfone groups. Additionally, the ROS produced by photosensitizer under light irradiation can also play the same role of H2O2. Such HBPMT micelles can be utilized to encapsulate anticancer drug paclitaxel (PTX) and photosensitizer chlorin e6 (Ce6) simultaneously for drug delivery and control release. The methyl thiazolyl tetrazolium assay toward MCF‐7 tumor cells (a human breast adenocarcinoma cell line) indicates that these micelles encapsulated with PTX and Ce6 exhibit a significant combinational efficacy of cell proliferation inhibition, which means the promising potential for synergistic chemo‐photodynamic cancer therapy. Such a novel nanocarrier based on amphiphilic to hydrophilic transition would provide a candidate for controlled drug release and cancer combination therapy. |
| first_indexed | 2024-12-10T23:59:18Z |
| format | Article |
| id | doaj.art-92d0d983d061459da5aa4ea88b9b07d8 |
| institution | Directory Open Access Journal |
| issn | 2688-819X |
| language | English |
| last_indexed | 2024-12-10T23:59:18Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | SmartMat |
| spelling | doaj.art-92d0d983d061459da5aa4ea88b9b07d82022-12-22T01:28:31ZengWileySmartMat2688-819X2022-09-013352253110.1002/smm2.1092ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug releaseGuanchun Wang0Ping Huang1Lei Wang2Xinliang Chen3Yongfeng Zhou4Wei Huang5Deyue Yan6School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai ChinaSchool of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai ChinaSchool of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai ChinaThe International Peace Maternity and Child Health Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaSchool of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai ChinaSchool of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai ChinaSchool of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai ChinaAbstract As a kind of promising drug carriers, smart polymers have attracted much attention due to the effective and controlled drug release in target cells. Herein, a reactive oxygen species (ROS)‐responsive thioether‐containing amphiphilic hyperbranched polymer prepared from MTPA and TMPTGE (HBPMT) is synthesized from 3‐(methylthio)propylamine (MTPA) and trimethylolpropane triglycidyl ether (TMPTGE) by the amine‐epoxy click reaction via A2 + B3 one‐pot approach. Benefiting from its inherent amphiphilic nature, HBPMT can self‐assemble into stable micelles in water. Triggered by H2O2, these micelles can be dissociated rapidly because hydrophobic thioether segments in their cores are oxidized into hydrophilic sulfoxide or sulfone groups. Additionally, the ROS produced by photosensitizer under light irradiation can also play the same role of H2O2. Such HBPMT micelles can be utilized to encapsulate anticancer drug paclitaxel (PTX) and photosensitizer chlorin e6 (Ce6) simultaneously for drug delivery and control release. The methyl thiazolyl tetrazolium assay toward MCF‐7 tumor cells (a human breast adenocarcinoma cell line) indicates that these micelles encapsulated with PTX and Ce6 exhibit a significant combinational efficacy of cell proliferation inhibition, which means the promising potential for synergistic chemo‐photodynamic cancer therapy. Such a novel nanocarrier based on amphiphilic to hydrophilic transition would provide a candidate for controlled drug release and cancer combination therapy.https://doi.org/10.1002/smm2.1092drug deliveryhyperbranched polymerphotosensitizerROS‐responsivenesstriggered drug release |
| spellingShingle | Guanchun Wang Ping Huang Lei Wang Xinliang Chen Yongfeng Zhou Wei Huang Deyue Yan ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release SmartMat drug delivery hyperbranched polymer photosensitizer ROS‐responsiveness triggered drug release |
| title | ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release |
| title_full | ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release |
| title_fullStr | ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release |
| title_full_unstemmed | ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release |
| title_short | ROS‐responsive thioether‐containing hyperbranched polymer micelles for light‐triggered drug release |
| title_sort | ros responsive thioether containing hyperbranched polymer micelles for light triggered drug release |
| topic | drug delivery hyperbranched polymer photosensitizer ROS‐responsiveness triggered drug release |
| url | https://doi.org/10.1002/smm2.1092 |
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