Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses
Cancer remains the second most common cause of death worldwide affecting around 10 million patients every year. Among the therapeutic options, chemotherapeutic drugs are widely used but often associated with side effects. In addition, toxicity against immune cells may hamper anti-tumor immune respon...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.731598/full |
| _version_ | 1818694140434579456 |
|---|---|
| author | Allan Scarpitta Ulrich T. Hacker Hildegard Büning Hildegard Büning Olivier Boyer Olivier Boyer Sahil Adriouch |
| author_facet | Allan Scarpitta Ulrich T. Hacker Hildegard Büning Hildegard Büning Olivier Boyer Olivier Boyer Sahil Adriouch |
| author_sort | Allan Scarpitta |
| collection | DOAJ |
| description | Cancer remains the second most common cause of death worldwide affecting around 10 million patients every year. Among the therapeutic options, chemotherapeutic drugs are widely used but often associated with side effects. In addition, toxicity against immune cells may hamper anti-tumor immune responses. Some chemotherapeutic drugs, however, preserve immune functions and some can even stimulate anti-tumor immune responses through the induction of immunogenic cell death (ICD) rather than apoptosis. ICD stimulates the immune system by several mechanisms including the release of damage-associated molecular patterns (DAMPs) from dying cells. In this review, we will discuss the consequences of inducing two recently characterized forms of ICD, i.e., pyroptosis and necroptosis, in the tumor microenvironment (TME) and the perspectives they may offer to increase the immunogenicity of the so-called cold tumors and to stimulate effective anti-tumor immune responses. |
| first_indexed | 2024-12-17T13:24:51Z |
| format | Article |
| id | doaj.art-92d156eaea2e41a3abe500f63393b19e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T13:24:51Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-92d156eaea2e41a3abe500f63393b19e2022-12-21T21:46:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-08-011110.3389/fonc.2021.731598731598Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune ResponsesAllan Scarpitta0Ulrich T. Hacker1Hildegard Büning2Hildegard Büning3Olivier Boyer4Olivier Boyer5Sahil Adriouch6UNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative Therapies, Normandie University, Rouen, FranceDepartment of Oncology, Gastroenterology, Hepatology, Pulmonology, and Infectious Diseases, University Cancer Center Leipzig (UCCL), University of Leipzig Medical Center, Leipzig, GermanyInstitute of Experimental Hematology, Hannover Medical School, Hannover, GermanyREBIRTH Research Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, GermanyUNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative Therapies, Normandie University, Rouen, FranceDepartment of Immunology and Biotherapy, Rouen University Hospital, Rouen, FranceUNIROUEN, INSERM, U1234, Pathophysiology, Autoimmunity, Neuromuscular Diseases and Regenerative Therapies, Normandie University, Rouen, FranceCancer remains the second most common cause of death worldwide affecting around 10 million patients every year. Among the therapeutic options, chemotherapeutic drugs are widely used but often associated with side effects. In addition, toxicity against immune cells may hamper anti-tumor immune responses. Some chemotherapeutic drugs, however, preserve immune functions and some can even stimulate anti-tumor immune responses through the induction of immunogenic cell death (ICD) rather than apoptosis. ICD stimulates the immune system by several mechanisms including the release of damage-associated molecular patterns (DAMPs) from dying cells. In this review, we will discuss the consequences of inducing two recently characterized forms of ICD, i.e., pyroptosis and necroptosis, in the tumor microenvironment (TME) and the perspectives they may offer to increase the immunogenicity of the so-called cold tumors and to stimulate effective anti-tumor immune responses.https://www.frontiersin.org/articles/10.3389/fonc.2021.731598/fullimmunogenic cell death and anti-tumor immunitypyroptosisnecroptosisanti-tumor immune responsestumor immune microenvironmentinflammation and immunity |
| spellingShingle | Allan Scarpitta Ulrich T. Hacker Hildegard Büning Hildegard Büning Olivier Boyer Olivier Boyer Sahil Adriouch Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses Frontiers in Oncology immunogenic cell death and anti-tumor immunity pyroptosis necroptosis anti-tumor immune responses tumor immune microenvironment inflammation and immunity |
| title | Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses |
| title_full | Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses |
| title_fullStr | Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses |
| title_full_unstemmed | Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses |
| title_short | Pyroptotic and Necroptotic Cell Death in the Tumor Microenvironment and Their Potential to Stimulate Anti-Tumor Immune Responses |
| title_sort | pyroptotic and necroptotic cell death in the tumor microenvironment and their potential to stimulate anti tumor immune responses |
| topic | immunogenic cell death and anti-tumor immunity pyroptosis necroptosis anti-tumor immune responses tumor immune microenvironment inflammation and immunity |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.731598/full |
| work_keys_str_mv | AT allanscarpitta pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses AT ulrichthacker pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses AT hildegardbuning pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses AT hildegardbuning pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses AT olivierboyer pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses AT olivierboyer pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses AT sahiladriouch pyroptoticandnecroptoticcelldeathinthetumormicroenvironmentandtheirpotentialtostimulateantitumorimmuneresponses |