3D printed multicompartmental capsules for a progressive drug release
The temporal delivery of chemical compounds to target organs and tissues is a key-topic for pharmacological and therapeutic applications. Dealing with ad hoc systems that can be properly designed to deliver drugs when are really needed is regarded as a valuable approach to improve the effectiveness...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Annals of 3D Printed Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666964121000217 |
| _version_ | 1818911529009938432 |
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| author | Liviana Russi Costantino Del Gaudio |
| author_facet | Liviana Russi Costantino Del Gaudio |
| author_sort | Liviana Russi |
| collection | DOAJ |
| description | The temporal delivery of chemical compounds to target organs and tissues is a key-topic for pharmacological and therapeutic applications. Dealing with ad hoc systems that can be properly designed to deliver drugs when are really needed is regarded as a valuable approach to improve the effectiveness of a clinical protocol. For this aim, 3D printing can be a suitable means to fabricate structured reservoirs to allow a prolonged release of the loaded pharmacological agent.This study reports the fabrication and characterization of multicompartmental capsules made of polyvinyl alcohol (PVA) processed by fused deposition modelling (FDM) to be considered for a time dependent release therapeutic approach. Thermal assessment of the printed devices was carried out to evaluate a possible influence of FDM high temperatures on the polymer, while dimensional consistency was evaluated through optical microscopy. Regarding the expected application, different designs were investigated in order to validate the proof-of-concept by in vitro assessing the release of curcumin, as a drug model. Three capsule models were tested, including single, double and triple reservoirs, which provided different dissolution periods, ranging from about 180 to 390 min.The collected results supported the potential to easily tailor 3D printed devices, specifically modified for drug delivery purposes. |
| first_indexed | 2024-12-19T23:00:09Z |
| format | Article |
| id | doaj.art-92d1809918da48209789ad20b8e1edc4 |
| institution | Directory Open Access Journal |
| issn | 2666-9641 |
| language | English |
| last_indexed | 2024-12-19T23:00:09Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of 3D Printed Medicine |
| spelling | doaj.art-92d1809918da48209789ad20b8e1edc42022-12-21T20:02:31ZengElsevierAnnals of 3D Printed Medicine2666-96412021-09-0131000263D printed multicompartmental capsules for a progressive drug releaseLiviana Russi0Costantino Del Gaudio1Graduate Student of Biomedical Engineering at Sapienza University of Rome, Via Eudossiana 18, 00184, Rome, ItalyE. Amaldi Foundation, Via del Politecnico snc, 00133 Rome, Italy; Hypatia Research Consortium, Via del Politecnico, 00133 Rome. Italy; Corresponding author.The temporal delivery of chemical compounds to target organs and tissues is a key-topic for pharmacological and therapeutic applications. Dealing with ad hoc systems that can be properly designed to deliver drugs when are really needed is regarded as a valuable approach to improve the effectiveness of a clinical protocol. For this aim, 3D printing can be a suitable means to fabricate structured reservoirs to allow a prolonged release of the loaded pharmacological agent.This study reports the fabrication and characterization of multicompartmental capsules made of polyvinyl alcohol (PVA) processed by fused deposition modelling (FDM) to be considered for a time dependent release therapeutic approach. Thermal assessment of the printed devices was carried out to evaluate a possible influence of FDM high temperatures on the polymer, while dimensional consistency was evaluated through optical microscopy. Regarding the expected application, different designs were investigated in order to validate the proof-of-concept by in vitro assessing the release of curcumin, as a drug model. Three capsule models were tested, including single, double and triple reservoirs, which provided different dissolution periods, ranging from about 180 to 390 min.The collected results supported the potential to easily tailor 3D printed devices, specifically modified for drug delivery purposes.http://www.sciencedirect.com/science/article/pii/S26669641210002173D printed delivery systemsMulticompartmental capsulesTime dependent drug release |
| spellingShingle | Liviana Russi Costantino Del Gaudio 3D printed multicompartmental capsules for a progressive drug release Annals of 3D Printed Medicine 3D printed delivery systems Multicompartmental capsules Time dependent drug release |
| title | 3D printed multicompartmental capsules for a progressive drug release |
| title_full | 3D printed multicompartmental capsules for a progressive drug release |
| title_fullStr | 3D printed multicompartmental capsules for a progressive drug release |
| title_full_unstemmed | 3D printed multicompartmental capsules for a progressive drug release |
| title_short | 3D printed multicompartmental capsules for a progressive drug release |
| title_sort | 3d printed multicompartmental capsules for a progressive drug release |
| topic | 3D printed delivery systems Multicompartmental capsules Time dependent drug release |
| url | http://www.sciencedirect.com/science/article/pii/S2666964121000217 |
| work_keys_str_mv | AT livianarussi 3dprintedmulticompartmentalcapsulesforaprogressivedrugrelease AT costantinodelgaudio 3dprintedmulticompartmentalcapsulesforaprogressivedrugrelease |