Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study
Abstract Background The renal function of the remaining kidney in living donors recovers up to 60~70% of pre-donation estimated-glomerular filtration rate (eGFR) by compensatory hypertrophy. However, the degree of this hypertrophy varies from donor to donor and the factors related to it are scarcely...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1588-3 |
| _version_ | 1819173748200177664 |
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| author | Sho Nishida Yuji Hidaka Mariko Toyoda Kohei Kinoshita Kosuke Tanaka Chiaki Kawabata Satoshi Hamanoue Akito Inadome Hiroshi Yokomizo Asami Takeda Soichi Uekihara Shigeyoshi Yamanaga |
| author_facet | Sho Nishida Yuji Hidaka Mariko Toyoda Kohei Kinoshita Kosuke Tanaka Chiaki Kawabata Satoshi Hamanoue Akito Inadome Hiroshi Yokomizo Asami Takeda Soichi Uekihara Shigeyoshi Yamanaga |
| author_sort | Sho Nishida |
| collection | DOAJ |
| description | Abstract Background The renal function of the remaining kidney in living donors recovers up to 60~70% of pre-donation estimated-glomerular filtration rate (eGFR) by compensatory hypertrophy. However, the degree of this hypertrophy varies from donor to donor and the factors related to it are scarcely known. Methods We analyzed 103 living renal transplantations in our institution and divided them into two groups: compensatory hypertrophy group [optimal group, 1-year eGFR ≥60% of pre-donation, n = 63] and suboptimal compensatory hypertrophy group (suboptimal group, 1-year eGFR < 60% of pre-donation, n = 40). We retrospectively analyzed the factors related to suboptimal compensatory hypertrophy. Results Baseline eGFRs were the same in the two groups (optimal versus suboptimal: 82.0 ± 13.1 ml/min/1.73m2 versus 83.5 ± 14.8 ml/min/1.73m2, p = 0.588). Donor age (optimal versus suboptimal: 56.0 ± 10.4 years old versus 60.7 ± 8.7 years old, p = 0.018) and uric acid (optimal versus suboptimal: 4.8 ± 1.2 mg/dl versus 5.5 ± 1.3 mg/dl, p = 0.007) were significantly higher in the suboptimal group. The rate of pathological chronicity finding on 1-h biopsy (ah≧1 ∩ ct + ci≧1) was much higher in the suboptimal group (optimal versus suboptimal: 6.4% versus 25.0%, p = 0.007). After the multivariate analysis, the pathological chronicity finding [odds ratio (OR): 4.8, 95% confidence interval (CI): 1.3–17.8, p = 0.021] and uric acid (per 1.0 mg/dl, OR: 1.5, 95% CI: 1.1–2.2, p = 0.022) were found to be independent risk factors for suboptimal compensatory hypertrophy. Conclusion Chronicity findings on baseline biopsy and higher uric acid were associated with insufficient recovery of the post-donated renal function. |
| first_indexed | 2024-12-22T20:28:00Z |
| format | Article |
| id | doaj.art-92d18a1e019a4e5f85218c8255d42ca2 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-22T20:28:00Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-92d18a1e019a4e5f85218c8255d42ca22022-12-21T18:13:41ZengBMCBMC Nephrology1471-23692019-11-012011710.1186/s12882-019-1588-3Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective studySho Nishida0Yuji Hidaka1Mariko Toyoda2Kohei Kinoshita3Kosuke Tanaka4Chiaki Kawabata5Satoshi Hamanoue6Akito Inadome7Hiroshi Yokomizo8Asami Takeda9Soichi Uekihara10Shigeyoshi Yamanaga11Department of General Surgery, Japanese Red Cross Kumamoto HospitalDepartment of General Surgery, Japanese Red Cross Kumamoto HospitalDepartment of Internal Medicine, Japanese Red Cross Kumamoto HospitalDepartment of General Surgery, Japanese Red Cross Kumamoto HospitalDepartment of General Surgery, Japanese Red Cross Kumamoto HospitalDepartment of Internal Medicine, Japanese Red Cross Kumamoto HospitalDepartment of Internal Medicine, Japanese Red Cross Kumamoto HospitalDepartment of Urology, Japanese Red Cross Kumamoto HospitalDepartment of General Surgery, Japanese Red Cross Kumamoto HospitalDepartment of Nephrology, Japanese Red Cross Nagoya Daini HospitalDepartment of Internal Medicine, Japanese Red Cross Kumamoto HospitalDepartment of General Surgery, Japanese Red Cross Kumamoto HospitalAbstract Background The renal function of the remaining kidney in living donors recovers up to 60~70% of pre-donation estimated-glomerular filtration rate (eGFR) by compensatory hypertrophy. However, the degree of this hypertrophy varies from donor to donor and the factors related to it are scarcely known. Methods We analyzed 103 living renal transplantations in our institution and divided them into two groups: compensatory hypertrophy group [optimal group, 1-year eGFR ≥60% of pre-donation, n = 63] and suboptimal compensatory hypertrophy group (suboptimal group, 1-year eGFR < 60% of pre-donation, n = 40). We retrospectively analyzed the factors related to suboptimal compensatory hypertrophy. Results Baseline eGFRs were the same in the two groups (optimal versus suboptimal: 82.0 ± 13.1 ml/min/1.73m2 versus 83.5 ± 14.8 ml/min/1.73m2, p = 0.588). Donor age (optimal versus suboptimal: 56.0 ± 10.4 years old versus 60.7 ± 8.7 years old, p = 0.018) and uric acid (optimal versus suboptimal: 4.8 ± 1.2 mg/dl versus 5.5 ± 1.3 mg/dl, p = 0.007) were significantly higher in the suboptimal group. The rate of pathological chronicity finding on 1-h biopsy (ah≧1 ∩ ct + ci≧1) was much higher in the suboptimal group (optimal versus suboptimal: 6.4% versus 25.0%, p = 0.007). After the multivariate analysis, the pathological chronicity finding [odds ratio (OR): 4.8, 95% confidence interval (CI): 1.3–17.8, p = 0.021] and uric acid (per 1.0 mg/dl, OR: 1.5, 95% CI: 1.1–2.2, p = 0.022) were found to be independent risk factors for suboptimal compensatory hypertrophy. Conclusion Chronicity findings on baseline biopsy and higher uric acid were associated with insufficient recovery of the post-donated renal function.http://link.springer.com/article/10.1186/s12882-019-1588-3Renal functionLiving donorKidney transplant |
| spellingShingle | Sho Nishida Yuji Hidaka Mariko Toyoda Kohei Kinoshita Kosuke Tanaka Chiaki Kawabata Satoshi Hamanoue Akito Inadome Hiroshi Yokomizo Asami Takeda Soichi Uekihara Shigeyoshi Yamanaga Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study BMC Nephrology Renal function Living donor Kidney transplant |
| title | Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study |
| title_full | Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study |
| title_fullStr | Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study |
| title_full_unstemmed | Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study |
| title_short | Factors related to suboptimal recovery of renal function after living donor nephrectomy: a retrospective study |
| title_sort | factors related to suboptimal recovery of renal function after living donor nephrectomy a retrospective study |
| topic | Renal function Living donor Kidney transplant |
| url | http://link.springer.com/article/10.1186/s12882-019-1588-3 |
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