A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care
This study compares knowledge, experience and understanding of genetic testing, and psychological outcomes among breast and ovarian cancer patients undergoing multi-gene panel testing via genetic counselor-mediated (GMT) or oncologist-mediated (OMT) testing models. A pragmatic, prospective survey of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/28/2/138 |
| _version_ | 1797520760033509376 |
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| author | Jeanna M. McCuaig Emily Thain Janet Malcolmson Sareh Keshavarzi Susan Randall Armel Raymond H. Kim |
| author_facet | Jeanna M. McCuaig Emily Thain Janet Malcolmson Sareh Keshavarzi Susan Randall Armel Raymond H. Kim |
| author_sort | Jeanna M. McCuaig |
| collection | DOAJ |
| description | This study compares knowledge, experience and understanding of genetic testing, and psychological outcomes among breast and ovarian cancer patients undergoing multi-gene panel testing via genetic counselor-mediated (GMT) or oncologist-mediated (OMT) testing models. A pragmatic, prospective survey of breast and ovarian cancer patients pursuing genetic testing between January 2017 and August 2019 was conducted at the Princess Margaret Cancer Centre in Toronto, Canada. A total of 120 (80 GMT; 40 OMT) individuals completed a survey administered one week following consent to genetic testing. Compared to OMT, the GMT cohort had higher median knowledge (8 vs. 9; <i>p</i> = 0.025) and experience/understanding scores (8.5 vs. 10; <i>p</i> < 0.001) at the time of genetic testing. Significant differences were noted in the potential psychological concerns experienced, with individuals in the GMT cohort more likely to screen positive in the hereditary predisposition domain of the Psychosocial Aspects of Hereditary Cancer tool (55% vs. 27.5%; <i>p</i> = 0.005), and individuals in the OMT cohort more likely to screen positive in the general emotions domain (65.0% vs. 38.8%; <i>p</i> = 0.007). The results of this study suggest that OMT can be implemented to streamline genetic testing; however, post-test genetic counseling should remain available to all individuals undergoing genetic testing, to ensure any psychologic concerns are addressed and that individuals have a clear understanding of relevant implications and limitations of their test results. |
| first_indexed | 2024-03-10T08:01:11Z |
| format | Article |
| id | doaj.art-92d275bc78794e4a924ba6b13403b483 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T08:01:11Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-92d275bc78794e4a924ba6b13403b4832023-11-22T11:29:20ZengMDPI AGCurrent Oncology1198-00521718-77292021-04-012821459147110.3390/curroncol28020138A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of CareJeanna M. McCuaig0Emily Thain1Janet Malcolmson2Sareh Keshavarzi3Susan Randall Armel4Raymond H. Kim5Familial Cancer Clinic, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, CanadaFamilial Cancer Clinic, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, CanadaFamilial Cancer Clinic, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, CanadaDepartment of Biostatistics, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, CanadaFamilial Cancer Clinic, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, CanadaFamilial Cancer Clinic, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, CanadaThis study compares knowledge, experience and understanding of genetic testing, and psychological outcomes among breast and ovarian cancer patients undergoing multi-gene panel testing via genetic counselor-mediated (GMT) or oncologist-mediated (OMT) testing models. A pragmatic, prospective survey of breast and ovarian cancer patients pursuing genetic testing between January 2017 and August 2019 was conducted at the Princess Margaret Cancer Centre in Toronto, Canada. A total of 120 (80 GMT; 40 OMT) individuals completed a survey administered one week following consent to genetic testing. Compared to OMT, the GMT cohort had higher median knowledge (8 vs. 9; <i>p</i> = 0.025) and experience/understanding scores (8.5 vs. 10; <i>p</i> < 0.001) at the time of genetic testing. Significant differences were noted in the potential psychological concerns experienced, with individuals in the GMT cohort more likely to screen positive in the hereditary predisposition domain of the Psychosocial Aspects of Hereditary Cancer tool (55% vs. 27.5%; <i>p</i> = 0.005), and individuals in the OMT cohort more likely to screen positive in the general emotions domain (65.0% vs. 38.8%; <i>p</i> = 0.007). The results of this study suggest that OMT can be implemented to streamline genetic testing; however, post-test genetic counseling should remain available to all individuals undergoing genetic testing, to ensure any psychologic concerns are addressed and that individuals have a clear understanding of relevant implications and limitations of their test results.https://www.mdpi.com/1718-7729/28/2/138genetic testinggenetic counselingmainstreamingservice delivery modelhereditary cancerbreast cancer |
| spellingShingle | Jeanna M. McCuaig Emily Thain Janet Malcolmson Sareh Keshavarzi Susan Randall Armel Raymond H. Kim A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care Current Oncology genetic testing genetic counseling mainstreaming service delivery model hereditary cancer breast cancer |
| title | A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care |
| title_full | A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care |
| title_fullStr | A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care |
| title_full_unstemmed | A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care |
| title_short | A Comparison of Patient-Reported Outcomes Following Consent for Genetic Testing Using an Oncologist- or Genetic Counselor-Mediated Model of Care |
| title_sort | comparison of patient reported outcomes following consent for genetic testing using an oncologist or genetic counselor mediated model of care |
| topic | genetic testing genetic counseling mainstreaming service delivery model hereditary cancer breast cancer |
| url | https://www.mdpi.com/1718-7729/28/2/138 |
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