The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation?
On computed tomography (CT) imaging, a peri-vascular adipose tissue attenuation (pVAT) measure has been proposed as a non-invasive correlate of inflammation in the coronary artery vessels, and a single research group provided histopathological demonstration of this radiological/pathological correspo...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/10/1799 |
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| author | Nicola Gaibazzi Domenico Tuttolomondo Francesco Nicolini Alessandro Tafuni Daniele Sartorio Chiara Martini Francesco Maestri Alan Gallingani Massimo De Filippo Domenico Corradi |
| author_facet | Nicola Gaibazzi Domenico Tuttolomondo Francesco Nicolini Alessandro Tafuni Daniele Sartorio Chiara Martini Francesco Maestri Alan Gallingani Massimo De Filippo Domenico Corradi |
| author_sort | Nicola Gaibazzi |
| collection | DOAJ |
| description | On computed tomography (CT) imaging, a peri-vascular adipose tissue attenuation (pVAT) measure has been proposed as a non-invasive correlate of inflammation in the coronary artery vessels, and a single research group provided histopathological demonstration of this radiological/pathological correspondence. Our group has shown that patients with surgical-grade ascending aorta (AA) aneurysm display higher pVAT compared with patients with smaller aneurysms or normal AA. Based on histopathological studies on coronary arteries, we speculated that this correlation may be related to a non-otherwise specified aortic inflammatory process. However, since adipose tissue around the AA is often scant, and there are no histopathological studies confirming such hypothesized association between higher pVAT and inflammation around the AA, we cannot exclude that this pVAT change is secondary to different mechanisms, unrelated to the actual presence of peri-vascular inflammation. We performed a retrospective clinical/radiological/pathological study in 78 patients who underwent AA surgery with the aim to correlate pre-operatory pVAT on CT with histopathological findings from the surgical specimens. Histopathological review and immunohistochemistry were performed on the surgical aortic samples. The AA adventitial/periadventitial adipose tissue had higher pVAT by an increasing collagen fiber deposition, which progressively makes the fat hypotrophic and, in the late stages of this process, it replaces the normal soft tissue composition in this location. In the ascending aorta, pVAT on CT imaging is probably not a proxy for the presence of current vascular inflammation, although it may track changes involving the progressive substitution of perivascular adipose cells by higher-pVAT tissues, mainly fibrotic replacement. |
| first_indexed | 2024-03-10T06:37:42Z |
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| id | doaj.art-92d2b67170554c5e84b1d35a1b2794af |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T06:37:42Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-92d2b67170554c5e84b1d35a1b2794af2023-11-22T17:56:56ZengMDPI AGDiagnostics2075-44182021-09-011110179910.3390/diagnostics11101799The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation?Nicola Gaibazzi0Domenico Tuttolomondo1Francesco Nicolini2Alessandro Tafuni3Daniele Sartorio4Chiara Martini5Francesco Maestri6Alan Gallingani7Massimo De Filippo8Domenico Corradi9Department of Cardiology, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Cardiology, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Cardiac Surgery, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyUnit of Pathology, Department of Medicine and Surgery, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Cardiology, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Radiology, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Cardiac Surgery, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Cardiac Surgery, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyDepartment of Medicine and Surgery, Section of Radiology, University of Parma, Maggiore Hospital, Via Gramsci 14, 43125 Parma, ItalyUnit of Pathology, Department of Medicine and Surgery, Parma University Hospital, Via Gramsci 14, 43125 Parma, ItalyOn computed tomography (CT) imaging, a peri-vascular adipose tissue attenuation (pVAT) measure has been proposed as a non-invasive correlate of inflammation in the coronary artery vessels, and a single research group provided histopathological demonstration of this radiological/pathological correspondence. Our group has shown that patients with surgical-grade ascending aorta (AA) aneurysm display higher pVAT compared with patients with smaller aneurysms or normal AA. Based on histopathological studies on coronary arteries, we speculated that this correlation may be related to a non-otherwise specified aortic inflammatory process. However, since adipose tissue around the AA is often scant, and there are no histopathological studies confirming such hypothesized association between higher pVAT and inflammation around the AA, we cannot exclude that this pVAT change is secondary to different mechanisms, unrelated to the actual presence of peri-vascular inflammation. We performed a retrospective clinical/radiological/pathological study in 78 patients who underwent AA surgery with the aim to correlate pre-operatory pVAT on CT with histopathological findings from the surgical specimens. Histopathological review and immunohistochemistry were performed on the surgical aortic samples. The AA adventitial/periadventitial adipose tissue had higher pVAT by an increasing collagen fiber deposition, which progressively makes the fat hypotrophic and, in the late stages of this process, it replaces the normal soft tissue composition in this location. In the ascending aorta, pVAT on CT imaging is probably not a proxy for the presence of current vascular inflammation, although it may track changes involving the progressive substitution of perivascular adipose cells by higher-pVAT tissues, mainly fibrotic replacement.https://www.mdpi.com/2075-4418/11/10/1799thoracic aortic aneurysmcomputed tomographyperivascular adipose tissue attenuationvascular inflammation |
| spellingShingle | Nicola Gaibazzi Domenico Tuttolomondo Francesco Nicolini Alessandro Tafuni Daniele Sartorio Chiara Martini Francesco Maestri Alan Gallingani Massimo De Filippo Domenico Corradi The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation? Diagnostics thoracic aortic aneurysm computed tomography perivascular adipose tissue attenuation vascular inflammation |
| title | The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation? |
| title_full | The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation? |
| title_fullStr | The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation? |
| title_full_unstemmed | The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation? |
| title_short | The Histopathological Correlate of Peri-Vascular Adipose Tissue Attenuation on Computed Tomography in Surgical Ascending Aorta Aneurysms: Is This a Measure of Tissue Inflammation? |
| title_sort | histopathological correlate of peri vascular adipose tissue attenuation on computed tomography in surgical ascending aorta aneurysms is this a measure of tissue inflammation |
| topic | thoracic aortic aneurysm computed tomography perivascular adipose tissue attenuation vascular inflammation |
| url | https://www.mdpi.com/2075-4418/11/10/1799 |
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