Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives
An important step in eukaryotic gene expression is the synthesis of proteins from mRNA, a process classically divided into three stages, initiation, elongation, and termination. Translation is a precisely regulated and conserved process in eukaryotes. The presence of plant-specific translation initi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fpls.2017.00644/full |
| _version_ | 1828975433351168000 |
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| author | M. Mar Castellano Ane Sesma Ane Sesma Carmen Castresana |
| author_facet | M. Mar Castellano Ane Sesma Ane Sesma Carmen Castresana |
| author_sort | M. Mar Castellano |
| collection | DOAJ |
| description | An important step in eukaryotic gene expression is the synthesis of proteins from mRNA, a process classically divided into three stages, initiation, elongation, and termination. Translation is a precisely regulated and conserved process in eukaryotes. The presence of plant-specific translation initiation factors and the lack of well-known translational regulatory pathways in this kingdom nonetheless indicate how a globally conserved process can diversify among organisms. The control of protein translation is a central aspect of plant development and adaptation to environmental stress, but the mechanisms are still poorly understood. Here we discuss current knowledge of the principal mechanisms that regulate translation initiation in plants, with special attention to the singularities of this eukaryotic kingdom. In addition, we highlight the major recent breakthroughs in the field and the main challenges to address in the coming years. |
| first_indexed | 2024-12-14T14:19:50Z |
| format | Article |
| id | doaj.art-92d49eeb609d4bc9bd275c7eab5cde1a |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-14T14:19:50Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-92d49eeb609d4bc9bd275c7eab5cde1a2022-12-21T22:58:06ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2017-04-01810.3389/fpls.2017.00644262139Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future PerspectivesM. Mar Castellano0Ane Sesma1Ane Sesma2Carmen Castresana3Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid – Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaMadrid, SpainCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid – Instituto Nacional de Investigación y Tecnología Agraria y AlimentariaMadrid, SpainDepartamento Biotecnología y Biología Vegetal, Universidad Politécnica de MadridMadrid, SpainCentro Nacional de Biotecnología – Consejo Superior de Investigaciones Científicas (CSIC)Madrid, SpainAn important step in eukaryotic gene expression is the synthesis of proteins from mRNA, a process classically divided into three stages, initiation, elongation, and termination. Translation is a precisely regulated and conserved process in eukaryotes. The presence of plant-specific translation initiation factors and the lack of well-known translational regulatory pathways in this kingdom nonetheless indicate how a globally conserved process can diversify among organisms. The control of protein translation is a central aspect of plant development and adaptation to environmental stress, but the mechanisms are still poorly understood. Here we discuss current knowledge of the principal mechanisms that regulate translation initiation in plants, with special attention to the singularities of this eukaryotic kingdom. In addition, we highlight the major recent breakthroughs in the field and the main challenges to address in the coming years.http://journal.frontiersin.org/article/10.3389/fpls.2017.00644/fulltranslation initiationstressplant developmentTOReIF2αeIF4E |
| spellingShingle | M. Mar Castellano Ane Sesma Ane Sesma Carmen Castresana Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives Frontiers in Plant Science translation initiation stress plant development TOR eIF2α eIF4E |
| title | Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives |
| title_full | Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives |
| title_fullStr | Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives |
| title_full_unstemmed | Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives |
| title_short | Regulation of Translation by TOR, eIF4E and eIF2α in Plants: Current Knowledge, Challenges and Future Perspectives |
| title_sort | regulation of translation by tor eif4e and eif2α in plants current knowledge challenges and future perspectives |
| topic | translation initiation stress plant development TOR eIF2α eIF4E |
| url | http://journal.frontiersin.org/article/10.3389/fpls.2017.00644/full |
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