Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment

Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment

Diabetes mellitus (DM) increases the destruction of periodontal tissue and impairs osteogenesis differentiation. Exendin-4 (Ex-4), a glucagon-like peptide-1 (GLP-1) analogue, can be used for treating DM and promotes bone regeneration. The aim of this study was to explore the effect and mechanism of...

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Bibliographic Details
Main Authors: Wang Min, Liu Min, Zheng Jiawen, Xiong Li, Wang Ping
Format: Article
Language:English
Published: De Gruyter 2023-04-01
Series:Open Medicine
Subjects:
exendin-4
osteogenic differentiation
pdlscs
high glucose
mapk signaling
wnt signaling
Online Access:https://doi.org/10.1515/med-2023-0692

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