Brain atrophy at onset and physical disability in multiple sclerosis
The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were i...
| Auteurs principaux: | , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Academia Brasileira de Neurologia (ABNEURO)
2012-10-01
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| Collection: | Arquivos de Neuro-Psiquiatria |
| Sujets: | |
| Accès en ligne: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003&lng=en&tlng=en |
| _version_ | 1828284537887522816 |
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| author | Juan Ignacio Rojas Liliana Patrucco Cristina Besada Laura Bengolea Edgardo Cristiano |
| author_facet | Juan Ignacio Rojas Liliana Patrucco Cristina Besada Laura Bengolea Edgardo Cristiano |
| author_sort | Juan Ignacio Rojas |
| collection | DOAJ |
| description | The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population. |
| first_indexed | 2024-04-13T09:02:26Z |
| format | Article |
| id | doaj.art-92d4e33e795b4d8d89f28f1a98e6ab1b |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-13T09:02:26Z |
| publishDate | 2012-10-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-92d4e33e795b4d8d89f28f1a98e6ab1b2022-12-22T02:53:05ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272012-10-01701076576810.1590/S0004-282X2012001000003S0004-282X2012001000003Brain atrophy at onset and physical disability in multiple sclerosisJuan Ignacio Rojas0Liliana Patrucco1Cristina Besada2Laura Bengolea3Edgardo Cristiano4Hospital Italiano de Buenos AiresHospital Italiano de Buenos AiresHospital Italiano de Buenos AiresHospital Italiano de Buenos AiresHospital Italiano de Buenos AiresThe aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS: MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categorized in three groups, EDSS=0, EDSS=1 and 2.5 and EDSS>2.5, and used as disability measure. RESULTS: Twenty-six patients were included. Mean atrophy during the first year in patients that reached an EDSS≥3 was -0.76±0.45 %, in patients with an EDSS between 1 and 2.5 was -0.59±0.56, while in patients with an EDSS of 0 it was -0.38±0.42 (p=0.003). DISCUSSION: Brain atrophy rates during the first year of disease were predictive of disease progression in our population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003&lng=en&tlng=enesclerosis múltipleatrofia cerebralExpanded Disability Status Scale |
| spellingShingle | Juan Ignacio Rojas Liliana Patrucco Cristina Besada Laura Bengolea Edgardo Cristiano Brain atrophy at onset and physical disability in multiple sclerosis Arquivos de Neuro-Psiquiatria esclerosis múltiple atrofia cerebral Expanded Disability Status Scale |
| title | Brain atrophy at onset and physical disability in multiple sclerosis |
| title_full | Brain atrophy at onset and physical disability in multiple sclerosis |
| title_fullStr | Brain atrophy at onset and physical disability in multiple sclerosis |
| title_full_unstemmed | Brain atrophy at onset and physical disability in multiple sclerosis |
| title_short | Brain atrophy at onset and physical disability in multiple sclerosis |
| title_sort | brain atrophy at onset and physical disability in multiple sclerosis |
| topic | esclerosis múltiple atrofia cerebral Expanded Disability Status Scale |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2012001000003&lng=en&tlng=en |
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