Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future
BackgroundNeurological and ophthalmological neurodegenerative diseases in large part share underlying biology and pathophysiology. Despite extensive preclinical research on neuroprotection that in many cases bridges and unifies both fields, only a handful of neuroprotective therapies have succeeded...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.964197/full |
| _version_ | 1828183938712993792 |
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| author | Leonard A. Levin Christopher Patrick Nozhat B. Choudry Najam A. Sharif Jeffrey L. Goldberg |
| author_facet | Leonard A. Levin Christopher Patrick Nozhat B. Choudry Najam A. Sharif Jeffrey L. Goldberg |
| author_sort | Leonard A. Levin |
| collection | DOAJ |
| description | BackgroundNeurological and ophthalmological neurodegenerative diseases in large part share underlying biology and pathophysiology. Despite extensive preclinical research on neuroprotection that in many cases bridges and unifies both fields, only a handful of neuroprotective therapies have succeeded clinically in either.Main bodyUnderstanding the commonalities among brain and neuroretinal neurodegenerations can help develop innovative ways to improve translational success in neuroprotection research and emerging therapies. To do this, analysis of why translational research in neuroprotection fails necessitates addressing roadblocks at basic research and clinical trial levels. These include optimizing translational approaches with respect to biomarkers, therapeutic targets, treatments, animal models, and regulatory pathways.ConclusionThe common features of neurological and ophthalmological neurodegenerations are useful for outlining a path forward that should increase the likelihood of translational success in neuroprotective therapies. |
| first_indexed | 2024-04-12T06:40:43Z |
| format | Article |
| id | doaj.art-92d4efcfb33d4ce99fa33aa6ae31e3ff |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T06:40:43Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-92d4efcfb33d4ce99fa33aa6ae31e3ff2022-12-22T03:43:45ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-08-011310.3389/fneur.2022.964197964197Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the futureLeonard A. Levin0Christopher Patrick1Nozhat B. Choudry2Najam A. Sharif3Jeffrey L. Goldberg4Departments of Ophthalmology and Visual Sciences, Neurology & Neurosurgery, McGill University, Montreal, QC, CanadaTELUS Health, Ottawa, ON, CanadaGlobal Alliances and External Research, Ophthalmology Innovation Center, Santen Inc., Emeryville, CA, United StatesGlobal Alliances and External Research, Ophthalmology Innovation Center, Santen Inc., Emeryville, CA, United StatesSpencer Center for Vision Research, Byers Eye Institute, Stanford University, Palo Alto, CA, United StatesBackgroundNeurological and ophthalmological neurodegenerative diseases in large part share underlying biology and pathophysiology. Despite extensive preclinical research on neuroprotection that in many cases bridges and unifies both fields, only a handful of neuroprotective therapies have succeeded clinically in either.Main bodyUnderstanding the commonalities among brain and neuroretinal neurodegenerations can help develop innovative ways to improve translational success in neuroprotection research and emerging therapies. To do this, analysis of why translational research in neuroprotection fails necessitates addressing roadblocks at basic research and clinical trial levels. These include optimizing translational approaches with respect to biomarkers, therapeutic targets, treatments, animal models, and regulatory pathways.ConclusionThe common features of neurological and ophthalmological neurodegenerations are useful for outlining a path forward that should increase the likelihood of translational success in neuroprotective therapies.https://www.frontiersin.org/articles/10.3389/fneur.2022.964197/fullneuroprotectionneurodegenerationtranslational failureAlzheimer's diseaseParkinson's diseaseamyotrophic lateral sclerosis |
| spellingShingle | Leonard A. Levin Christopher Patrick Nozhat B. Choudry Najam A. Sharif Jeffrey L. Goldberg Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future Frontiers in Neurology neuroprotection neurodegeneration translational failure Alzheimer's disease Parkinson's disease amyotrophic lateral sclerosis |
| title | Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future |
| title_full | Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future |
| title_fullStr | Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future |
| title_full_unstemmed | Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future |
| title_short | Neuroprotection in neurodegenerations of the brain and eye: Lessons from the past and directions for the future |
| title_sort | neuroprotection in neurodegenerations of the brain and eye lessons from the past and directions for the future |
| topic | neuroprotection neurodegeneration translational failure Alzheimer's disease Parkinson's disease amyotrophic lateral sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.964197/full |
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