Requirement of the Ca2+ channel β2 subunit for sympathetic PKA phosphorylation

Requirement of the Ca2+ channel β2 subunit for sympathetic PKA phosphorylation

Facilitation of cardiac function in response to signals from the sympathetic nervous system is initiated by the phosphorylation of L-type voltage-dependent Ca2+ channels (VDCCs) by protein kinase A (PKA), which in turn is activated by β-adrenoceptors. Among the five subunits (α1, β, α2/δ, and γ) of...

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Bibliographic Details
Main Authors: Manabu Murakami, Feng Xu, Takayoshi Ohba, Takeshi Kobayashi, Yoshiro Inoue, Agnieszka M. Murakami, Ichiro Miyoshi, Kyoichi Ono, Noritsugu Tohse
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Calcium
Channel
Mouse
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320301304

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