Emerging issues in probiotic safety: 2023 perspectives
ABSTRACTProbiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics into vulnerable populations, warrants concise, and ac...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2185034 |
| _version_ | 1797236665674104832 |
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| author | Daniel Merenstein Bruno Pot Gregory Leyer Arthur C. Ouwehand Geoffrey A. Preidis Christopher A. Elkins Colin Hill Zachery T. Lewis Andi L. Shane Niv Zmora Mariya I. Petrova Maria Carmen Collado Lorenzo Morelli Gina A. Montoya Hania Szajewska Daniel J. Tancredi Mary Ellen Sanders |
| author_facet | Daniel Merenstein Bruno Pot Gregory Leyer Arthur C. Ouwehand Geoffrey A. Preidis Christopher A. Elkins Colin Hill Zachery T. Lewis Andi L. Shane Niv Zmora Mariya I. Petrova Maria Carmen Collado Lorenzo Morelli Gina A. Montoya Hania Szajewska Daniel J. Tancredi Mary Ellen Sanders |
| author_sort | Daniel Merenstein |
| collection | DOAJ |
| description | ABSTRACTProbiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics into vulnerable populations, warrants concise, and actionable recommendations on how to work toward their safe and effective use. The International Scientific Association for Probiotics and Prebiotics convened a meeting to discuss and produce evidence-based recommendations on potential acute and long-term risks, risks to vulnerable populations, the importance for probiotic product quality to match the needs of vulnerable populations, and the need for adverse event reporting related to probiotic use. The importance of whole genome sequencing, which enables determination of virulence, toxin, and antibiotic resistance genes, as well as clear assignment of species and strain identity, is emphasized. We present recommendations to guide the scientific and medical community on judging probiotic safety. |
| first_indexed | 2024-03-11T14:20:32Z |
| format | Article |
| id | doaj.art-92d639aa35ab4275b35bc3ded3e1cfb2 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-04-24T17:07:28Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-92d639aa35ab4275b35bc3ded3e1cfb22024-03-28T22:38:20ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115110.1080/19490976.2023.2185034Emerging issues in probiotic safety: 2023 perspectivesDaniel Merenstein0Bruno Pot1Gregory Leyer2Arthur C. Ouwehand3Geoffrey A. Preidis4Christopher A. Elkins5Colin Hill6Zachery T. Lewis7Andi L. Shane8Niv Zmora9Mariya I. Petrova10Maria Carmen Collado11Lorenzo Morelli12Gina A. Montoya13Hania Szajewska14Daniel J. Tancredi15Mary Ellen Sanders16Department of Family Medicine, Georgetown University Medical Center, Washington, DC USAYakult Europe BV, Almere, NetherlandsScientific Affairs, Chr. Hansen, Milwaukee, WI, USAGlobal Health & Nutrition Sciences, International Flavors & Fragrances, Kantvik, FinlandDivision of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Baylor College of Medicine and Texas Children’s Hospital, Houston, TX, USAClinical and Environmental Microbiology Branch, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USAAPC Microbiome Ireland, University College Cork, Cork, IrelandSynbiotic Health Inc, Lincoln, NE, USADivision of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Emory Children’s Center, Atlanta, GeorgiaScientific consultant, Elinav Lab, Immunology Department, Weizmann Institute of Science, Department of Gastroenterology and Liver Diseases, Tel Aviv, IsraelWinclove Probiotics B.V., Amsterdam, The NetherlandsInstitute of Agrochemistry and Food Technology-National Research Council (IATA-CSIC), Valencia, SpainDepartment of Food Science and Technology, Università Cattolica del Sacro Cuore, Piacenza, ItalyDepartment of Chemical Risk Assessment, Nestlé S.A., Lausanne, SwitzerlandDepartment of Paediatrics, The Medical University of Warsaw, Warsaw, PolandDepartment of Pediatrics, UC Davis School of Medicine, Sacramento, CA, USAInternational Scientific Association for Probiotics and Prebiotics, Centennial, CO, USAABSTRACTProbiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics into vulnerable populations, warrants concise, and actionable recommendations on how to work toward their safe and effective use. The International Scientific Association for Probiotics and Prebiotics convened a meeting to discuss and produce evidence-based recommendations on potential acute and long-term risks, risks to vulnerable populations, the importance for probiotic product quality to match the needs of vulnerable populations, and the need for adverse event reporting related to probiotic use. The importance of whole genome sequencing, which enables determination of virulence, toxin, and antibiotic resistance genes, as well as clear assignment of species and strain identity, is emphasized. We present recommendations to guide the scientific and medical community on judging probiotic safety.https://www.tandfonline.com/doi/10.1080/19490976.2023.2185034Probioticsafetynext-generation probioticsantibiotic resistancemicrobiomemicrobiota |
| spellingShingle | Daniel Merenstein Bruno Pot Gregory Leyer Arthur C. Ouwehand Geoffrey A. Preidis Christopher A. Elkins Colin Hill Zachery T. Lewis Andi L. Shane Niv Zmora Mariya I. Petrova Maria Carmen Collado Lorenzo Morelli Gina A. Montoya Hania Szajewska Daniel J. Tancredi Mary Ellen Sanders Emerging issues in probiotic safety: 2023 perspectives Gut Microbes Probiotic safety next-generation probiotics antibiotic resistance microbiome microbiota |
| title | Emerging issues in probiotic safety: 2023 perspectives |
| title_full | Emerging issues in probiotic safety: 2023 perspectives |
| title_fullStr | Emerging issues in probiotic safety: 2023 perspectives |
| title_full_unstemmed | Emerging issues in probiotic safety: 2023 perspectives |
| title_short | Emerging issues in probiotic safety: 2023 perspectives |
| title_sort | emerging issues in probiotic safety 2023 perspectives |
| topic | Probiotic safety next-generation probiotics antibiotic resistance microbiome microbiota |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2185034 |
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