<it>MGMT </it>promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR

<it>MGMT </it>promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR

<p>Abstract</p> <p>Background</p> <p>Methylation of the O<sup>6</sup>-methylguanine-DNA methyltransferase (<it>MGMT</it>) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary sign...

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Bibliographic Details
Main Authors: Håvik Annette, Brandal Petter, Honne Hilde, Dahlback Hanne-Sofie, Scheie David, Hektoen Merete, Meling Torstein, Helseth Eirik, Heim Sverre, Lothe Ragnhild A, Lind Guro
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Translational Medicine
Subjects:
Glioma
Glioblastoma
<it>MGMT</it>
Methylation
Gene expression
Low-grade glioma
High-grade gliomas
Pyrosequencing
qMSP
RT-PCR
Online Access:http://www.translational-medicine.com/content/10/1/36

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