An overview of substrate stiffness guided cellular response and its applications in tissue regeneration
Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual uncovering of substrate mechanical characteristics that can affect cell-matrix interactions, much progress has been made to unravel substrate stiffness-mediated cellular response as well as its underlying m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2022-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X21005600 |
| _version_ | 1827280245729787904 |
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| author | Bingcheng Yi Qi Xu Wei Liu |
| author_facet | Bingcheng Yi Qi Xu Wei Liu |
| author_sort | Bingcheng Yi |
| collection | DOAJ |
| description | Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual uncovering of substrate mechanical characteristics that can affect cell-matrix interactions, much progress has been made to unravel substrate stiffness-mediated cellular response as well as its underlying mechanisms. Yet, as a part of cell-matrix interaction biology, this field remains in its infancy, and the detailed molecular mechanisms are still elusive regarding scaffold-modulated tissue regeneration. This review provides an overview of recent progress in the area of the substrate stiffness-mediated cellular responses, including 1) the physical determination of substrate stiffness on cell fate and tissue development; 2) the current exploited approaches to manipulate the stiffness of scaffolds; 3) the progress of recent researches to reveal the role of substrate stiffness in cellular responses in some representative tissue-engineered regeneration varying from stiff tissue to soft tissue. This article aims to provide an up-to-date overview of cell mechanobiology research in substrate stiffness mediated cellular response and tissue regeneration with insightful information to facilitate interdisciplinary knowledge transfer and enable the establishment of prognostic markers for the design of suitable biomaterials. |
| first_indexed | 2024-04-12T11:25:35Z |
| format | Article |
| id | doaj.art-92d7ac55af7d4ea497a248edfd416e95 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:33:39Z |
| publishDate | 2022-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-92d7ac55af7d4ea497a248edfd416e952024-04-16T18:34:14ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-09-011582102An overview of substrate stiffness guided cellular response and its applications in tissue regenerationBingcheng Yi0Qi Xu1Wei Liu2Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, ChinaPlastic Surgery Research Institute, Weifang Medical University, Weifang, 261042, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Plastic Surgery Research Institute, Weifang Medical University, Weifang, 261042, China; Corresponding author. Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai, 200011, China.Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual uncovering of substrate mechanical characteristics that can affect cell-matrix interactions, much progress has been made to unravel substrate stiffness-mediated cellular response as well as its underlying mechanisms. Yet, as a part of cell-matrix interaction biology, this field remains in its infancy, and the detailed molecular mechanisms are still elusive regarding scaffold-modulated tissue regeneration. This review provides an overview of recent progress in the area of the substrate stiffness-mediated cellular responses, including 1) the physical determination of substrate stiffness on cell fate and tissue development; 2) the current exploited approaches to manipulate the stiffness of scaffolds; 3) the progress of recent researches to reveal the role of substrate stiffness in cellular responses in some representative tissue-engineered regeneration varying from stiff tissue to soft tissue. This article aims to provide an up-to-date overview of cell mechanobiology research in substrate stiffness mediated cellular response and tissue regeneration with insightful information to facilitate interdisciplinary knowledge transfer and enable the establishment of prognostic markers for the design of suitable biomaterials.http://www.sciencedirect.com/science/article/pii/S2452199X21005600Substrate stiffnessCellular responseCell-matrix interactionMechanobiologyTissue engineering |
| spellingShingle | Bingcheng Yi Qi Xu Wei Liu An overview of substrate stiffness guided cellular response and its applications in tissue regeneration Bioactive Materials Substrate stiffness Cellular response Cell-matrix interaction Mechanobiology Tissue engineering |
| title | An overview of substrate stiffness guided cellular response and its applications in tissue regeneration |
| title_full | An overview of substrate stiffness guided cellular response and its applications in tissue regeneration |
| title_fullStr | An overview of substrate stiffness guided cellular response and its applications in tissue regeneration |
| title_full_unstemmed | An overview of substrate stiffness guided cellular response and its applications in tissue regeneration |
| title_short | An overview of substrate stiffness guided cellular response and its applications in tissue regeneration |
| title_sort | overview of substrate stiffness guided cellular response and its applications in tissue regeneration |
| topic | Substrate stiffness Cellular response Cell-matrix interaction Mechanobiology Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X21005600 |
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