TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17978-9 |
| _version_ | 1819198487608164352 |
|---|---|
| author | Tatjana Lalic Aiste Steponenaite Liting Wei Sridhar R. Vasudevan Alistair Mathie Stuart N. Peirson Gurprit S. Lall M. Zameel Cader |
| author_facet | Tatjana Lalic Aiste Steponenaite Liting Wei Sridhar R. Vasudevan Alistair Mathie Stuart N. Peirson Gurprit S. Lall M. Zameel Cader |
| author_sort | Tatjana Lalic |
| collection | DOAJ |
| description | The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes. |
| first_indexed | 2024-12-23T03:01:14Z |
| format | Article |
| id | doaj.art-92d80056b5bc4ccbb603e1addb6b05b5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T03:01:14Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-92d80056b5bc4ccbb603e1addb6b05b52022-12-21T18:02:26ZengNature PortfolioNature Communications2041-17232020-09-0111111110.1038/s41467-020-17978-9TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responsesTatjana Lalic0Aiste Steponenaite1Liting Wei2Sridhar R. Vasudevan3Alistair Mathie4Stuart N. Peirson5Gurprit S. Lall6M. Zameel Cader7Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of OxfordMedway School of Pharmacy, University of Kent and University of GreenwichTranslational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of OxfordDepartment of Pharmacology, University of OxfordMedway School of Pharmacy, University of Kent and University of GreenwichSleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of OxfordMedway School of Pharmacy, University of Kent and University of GreenwichTranslational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of OxfordThe suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes.https://doi.org/10.1038/s41467-020-17978-9 |
| spellingShingle | Tatjana Lalic Aiste Steponenaite Liting Wei Sridhar R. Vasudevan Alistair Mathie Stuart N. Peirson Gurprit S. Lall M. Zameel Cader TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses Nature Communications |
| title | TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses |
| title_full | TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses |
| title_fullStr | TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses |
| title_full_unstemmed | TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses |
| title_short | TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses |
| title_sort | tresk is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses |
| url | https://doi.org/10.1038/s41467-020-17978-9 |
| work_keys_str_mv | AT tatjanalalic treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT aistesteponenaite treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT litingwei treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT sridharrvasudevan treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT alistairmathie treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT stuartnpeirson treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT gurpritslall treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses AT mzameelcader treskisakeyregulatorofnocturnalsuprachiasmaticnucleusdynamicsandlightadaptiveresponses |