Lethal and semi-lethal mutations in Holstein calves in Uruguay
ABSTRACT: Genetic disorders in Holstein cattle are a health problem that has grown worldwide in recent years, compromising the sustainability of modern dairy production. In Uruguay, Holstein-based milk production is one of the most important sectors of the country’s economy, but high levels of inbre...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Santa Maria
2021-04-01
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| Series: | Ciência Rural |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700652&tlng=en |
| _version_ | 1818974996189413376 |
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| author | Carolina Briano-Rodriguez Agustín Romero Silvia Llambí Andrea Branda Sica María Teresa Federici Rodriguez Federico Giannitti Rubén Dario Caffarena Carlos Omar Schild María Laura Casaux Fernando Dutra Quintela |
| author_facet | Carolina Briano-Rodriguez Agustín Romero Silvia Llambí Andrea Branda Sica María Teresa Federici Rodriguez Federico Giannitti Rubén Dario Caffarena Carlos Omar Schild María Laura Casaux Fernando Dutra Quintela |
| author_sort | Carolina Briano-Rodriguez |
| collection | DOAJ |
| description | ABSTRACT: Genetic disorders in Holstein cattle are a health problem that has grown worldwide in recent years, compromising the sustainability of modern dairy production. In Uruguay, Holstein-based milk production is one of the most important sectors of the country’s economy, but high levels of inbreeding have decreased the breed’s fertility in recent decades. This study investigated the presence and diffusion of lethal and semi-lethal alleles causing embryo death, abortions, fetal malformations, and neonatal diseases in Holstein calves. Using the GeneSeek® Genomic Profiler™ Bovine 50K BeadChip, we genotyped 383 calves (1-30 days-old) from 27 farms located in the main dairy region of Uruguay. Results showed a high prevalence of farms (85%) and carrier calves (21%), including one or more of the following semi-lethal or lethal alleles: Syndactylism (4.18%), brachyspina (3.39%), cholesterol deficiency haplotype (2.61%), complex vertebral malformation (2.09%), bovine leukocyte adhesion deficiency (1.04%s), and Holstein haplotypes HH1 (4.44%), HH3 (3.13%), HH4 (1.04%), and HH5 (0.26%). Most of these alleles had not been recognized previously in Uruguay. We concluded that lethal and semi-lethal mutations are widespread in the Holstein breed in Uruguay. More studies are required to determine their impact on dairy cattle fertility. |
| first_indexed | 2024-12-20T15:48:56Z |
| format | Article |
| id | doaj.art-92d97bf91ae5490cbc9251d0ae7dc87d |
| institution | Directory Open Access Journal |
| issn | 1678-4596 |
| language | English |
| last_indexed | 2024-12-20T15:48:56Z |
| publishDate | 2021-04-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj.art-92d97bf91ae5490cbc9251d0ae7dc87d2022-12-21T19:34:48ZengUniversidade Federal de Santa MariaCiência Rural1678-45962021-04-0151710.1590/0103-8478cr20200734Lethal and semi-lethal mutations in Holstein calves in UruguayCarolina Briano-Rodriguezhttps://orcid.org/0000-0002-5295-9550Agustín Romerohttps://orcid.org/0000-0001-5110-1846Silvia Llambíhttps://orcid.org/0000-0003-2594-9338Andrea Branda Sicahttps://orcid.org/0000-0002-4919-2563María Teresa Federici Rodriguezhttps://orcid.org/0000-0002-2795-4635Federico Giannittihttps://orcid.org/0000-0001-8799-6848Rubén Dario Caffarenahttps://orcid.org/0000-0002-2141-3264Carlos Omar Schildhttps://orcid.org/0000-0002-7851-3039María Laura Casauxhttps://orcid.org/0000-0002-6736-4816Fernando Dutra Quintelahttps://orcid.org/0000-0003-4886-9429ABSTRACT: Genetic disorders in Holstein cattle are a health problem that has grown worldwide in recent years, compromising the sustainability of modern dairy production. In Uruguay, Holstein-based milk production is one of the most important sectors of the country’s economy, but high levels of inbreeding have decreased the breed’s fertility in recent decades. This study investigated the presence and diffusion of lethal and semi-lethal alleles causing embryo death, abortions, fetal malformations, and neonatal diseases in Holstein calves. Using the GeneSeek® Genomic Profiler™ Bovine 50K BeadChip, we genotyped 383 calves (1-30 days-old) from 27 farms located in the main dairy region of Uruguay. Results showed a high prevalence of farms (85%) and carrier calves (21%), including one or more of the following semi-lethal or lethal alleles: Syndactylism (4.18%), brachyspina (3.39%), cholesterol deficiency haplotype (2.61%), complex vertebral malformation (2.09%), bovine leukocyte adhesion deficiency (1.04%s), and Holstein haplotypes HH1 (4.44%), HH3 (3.13%), HH4 (1.04%), and HH5 (0.26%). Most of these alleles had not been recognized previously in Uruguay. We concluded that lethal and semi-lethal mutations are widespread in the Holstein breed in Uruguay. More studies are required to determine their impact on dairy cattle fertility.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700652&tlng=enbovine hereditary diseasesbrachyspinaHolstein haplotypessyndactylycholesterol deficiencycomplex vertebral malformationBLAD |
| spellingShingle | Carolina Briano-Rodriguez Agustín Romero Silvia Llambí Andrea Branda Sica María Teresa Federici Rodriguez Federico Giannitti Rubén Dario Caffarena Carlos Omar Schild María Laura Casaux Fernando Dutra Quintela Lethal and semi-lethal mutations in Holstein calves in Uruguay Ciência Rural bovine hereditary diseases brachyspina Holstein haplotypes syndactyly cholesterol deficiency complex vertebral malformation BLAD |
| title | Lethal and semi-lethal mutations in Holstein calves in Uruguay |
| title_full | Lethal and semi-lethal mutations in Holstein calves in Uruguay |
| title_fullStr | Lethal and semi-lethal mutations in Holstein calves in Uruguay |
| title_full_unstemmed | Lethal and semi-lethal mutations in Holstein calves in Uruguay |
| title_short | Lethal and semi-lethal mutations in Holstein calves in Uruguay |
| title_sort | lethal and semi lethal mutations in holstein calves in uruguay |
| topic | bovine hereditary diseases brachyspina Holstein haplotypes syndactyly cholesterol deficiency complex vertebral malformation BLAD |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000700652&tlng=en |
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