Combined Deficiency of the Melanocortin 5 Receptor and Adenosine 2A Receptor Unexpectedly Provides Resistance to Autoimmune Disease in a CD8+ T Cell-Dependent Manner

Combined Deficiency of the Melanocortin 5 Receptor and Adenosine 2A Receptor Unexpectedly Provides Resistance to Autoimmune Disease in a CD8+ T Cell-Dependent Manner

Regulatory immunity that provides resistance to relapse emerges during resolution of experimental autoimmune uveitis (EAU). This post-EAU regulatory immunity requires a melanocortin 5 receptor (MC5r)-dependent suppressor antigen presenting cell (APC), as shown using a MC5r single knock-out mouse. Th...

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Bibliographic Details
Main Authors: Trisha McDonald, Fauziyya Muhammad, Kayleigh Peters, Darren J. Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
autoimmune uveitis
A2a adenosine receptor (A2Ar)
melanocortin 5 receptor
Treg - regulatory T cell
CD8 T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.742154/full

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