BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma
Background: Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular m...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Dental Research |
| Subjects: | |
| Online Access: | http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=2;spage=196;epage=200;aulast=Shukla |
| _version_ | 1811215251908067328 |
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| author | Payal Shukla Sudeendra Prabhu Maji Jose B H Sripathi Rao |
| author_facet | Payal Shukla Sudeendra Prabhu Maji Jose B H Sripathi Rao |
| author_sort | Payal Shukla |
| collection | DOAJ |
| description | Background: Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular methods, especially in tumor progression tests and Bcl-X is an important antiapoptotic member of the Bcl-2 family and is one of the newest and most useful markers to determine the aggressiveness of many carcinomas. The relationship between this Bcl-X protein and carcinomatous behavior toward it is not studied extensively, which we attempted to evaluate using immunohistochemical analysis in selected carcinomas of the head and neck region. Method: We studied Bcl-X protein expression in sections of thirty OSCC and ten VC samples and correlated this with tumor differentiation. Results: There was a significant difference in cytoplasmic staining of Bcl-X expression with statistical analysis (P < 0.005) for VC and OSCC when compared as a group. No significance was seen among the different histological grades of OSCC and when compared with VC individually. Conclusion: The significant result between OSCC and VC suggests that their biologic course is comparable and can be helpful in differentiating them with each other for establishment of a better treatment protocol. |
| first_indexed | 2024-04-12T06:18:14Z |
| format | Article |
| id | doaj.art-92dd8e44df4d4419aa73cf5f0da209ee |
| institution | Directory Open Access Journal |
| issn | 0970-9290 1998-3603 |
| language | English |
| last_indexed | 2024-04-12T06:18:14Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dental Research |
| spelling | doaj.art-92dd8e44df4d4419aa73cf5f0da209ee2022-12-22T03:44:23ZengWolters Kluwer Medknow PublicationsIndian Journal of Dental Research0970-92901998-36032018-01-0129219620010.4103/ijdr.IJDR_711_16BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinomaPayal ShuklaSudeendra PrabhuMaji JoseB H Sripathi RaoBackground: Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular methods, especially in tumor progression tests and Bcl-X is an important antiapoptotic member of the Bcl-2 family and is one of the newest and most useful markers to determine the aggressiveness of many carcinomas. The relationship between this Bcl-X protein and carcinomatous behavior toward it is not studied extensively, which we attempted to evaluate using immunohistochemical analysis in selected carcinomas of the head and neck region. Method: We studied Bcl-X protein expression in sections of thirty OSCC and ten VC samples and correlated this with tumor differentiation. Results: There was a significant difference in cytoplasmic staining of Bcl-X expression with statistical analysis (P < 0.005) for VC and OSCC when compared as a group. No significance was seen among the different histological grades of OSCC and when compared with VC individually. Conclusion: The significant result between OSCC and VC suggests that their biologic course is comparable and can be helpful in differentiating them with each other for establishment of a better treatment protocol.http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=2;spage=196;epage=200;aulast=ShuklaBcl-2Bcl-Xoral squamous cell carcinomaverrucous carcinoma |
| spellingShingle | Payal Shukla Sudeendra Prabhu Maji Jose B H Sripathi Rao BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma Indian Journal of Dental Research Bcl-2 Bcl-X oral squamous cell carcinoma verrucous carcinoma |
| title | BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma |
| title_full | BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma |
| title_fullStr | BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma |
| title_full_unstemmed | BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma |
| title_short | BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma |
| title_sort | bcl x expression in oral cancer comparison between oral squamous cell carcinoma and verrucous carcinoma |
| topic | Bcl-2 Bcl-X oral squamous cell carcinoma verrucous carcinoma |
| url | http://www.ijdr.in/article.asp?issn=0970-9290;year=2018;volume=29;issue=2;spage=196;epage=200;aulast=Shukla |
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