Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling

Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling

Disturbance in a differentiation program of skeletal stem cells leads to indecorous skeletogenesis. Growing evidence suggests that a fine-tuning of ubiquitin-mediated protein degradation is crucial for skeletal stem cells to maintain their stemness and osteogenic potential. Here, we demonstrate that...

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Bibliographic Details
Main Authors: Sachin Chaugule, Jung-Min Kim, Yeon-Suk Yang, Klaus-Peter Knobeloch, Xi He, Jae-Hyuck Shim
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
USP8
deubiquitinating enzyme
osteoblast
FZD5
Wnt signaling
skeletogenesis
Online Access:https://www.mdpi.com/1422-0067/22/19/10289

Internet

https://www.mdpi.com/1422-0067/22/19/10289

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