Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia‐Reperfusion

Cardiac Overexpression of S100A6 Attenuates Cardiomyocyte Apoptosis and Reduces Infarct Size After Myocardial Ischemia‐Reperfusion

BackgroundCardiomyocyte‐specific transgenic mice overexpressing S100A6, a member of the family of EF‐hand calcium‐binding proteins, develop less cardiac hypertrophy, interstitial fibrosis, and myocyte apoptosis after permanent coronary ligation, findings that support S100A6 as a potential therapeuti...

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Bibliographic Details
Main Authors: Azadeh Mofid, Nadav S. Newman, Paul J. H. Lee, Cynthia Abbasi, Pratiek N. Matkar, Dmitriy Rudenko, Michael A. Kuliszewski, Hao H. Chen, Kolsoom Afrasiabi, James N. Tsoporis, Anthony O. Gramolini, Kim A. Connelly, Thomas G. Parker, Howard Leong‐Poi
Format: Article
Language:English
Published: Wiley 2017-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
apoptosis
gene therapy
hypertrophy
ischemia‐reperfusion
S100A6
ultrasound‐targeted microbubble destruction
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.116.004738

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