Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature
Background: Endometrial cancer is the most common gynaecological tumour in developed countries. The overall rate of relapse has remained unchanged in recent decades. Recurrences occur in approximately 20% of endometrioid and 50% of non-endometrioid cases. The aim of this systematic review is to comp...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/17/4176 |
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| author | Stefano Restaino Giorgia Dinoi Eleonora La Fera Benedetta Gui Serena Cappuccio Maura Campitelli Giuseppe Vizzielli Giovanni Scambia Francesco Fanfani |
| author_facet | Stefano Restaino Giorgia Dinoi Eleonora La Fera Benedetta Gui Serena Cappuccio Maura Campitelli Giuseppe Vizzielli Giovanni Scambia Francesco Fanfani |
| author_sort | Stefano Restaino |
| collection | DOAJ |
| description | Background: Endometrial cancer is the most common gynaecological tumour in developed countries. The overall rate of relapse has remained unchanged in recent decades. Recurrences occur in approximately 20% of endometrioid and 50% of non-endometrioid cases. The aim of this systematic review is to compare different therapeutic strategies in the treatment of endometrial cancer recurrence to evaluate their prognostic and curative effects based on site and type of recurrence. Methods: This systematic review of literature was conducted in accordance with the PRISMA guidelines. The study protocol was registered on PROSPERO (CRD42020154042). PubMed, Embase, Chocrane and Cinahl databases were searched from January 1995 to September 2021. Five retrospective studies were selected. Results: A total of 3571 studies were included in the initial search. Applying the screening criteria, 299 articles were considered eligible for full-text reading, of which, after applying the exclusion criteria, 4 studies were selected for the final analysis and included in the systematic review. No studies were included for a quantitative analysis. We divided the results according to the location of the recurrence: locoregional recurrence, abdominal recurrence and extra abdominal recurrence. Conclusion: the treatment of choice should be assessed according to the relapse location and to the presence of single or multiple lesions. A crucial role in the decision-making algorithm is also the type of adjuvant treatment received at the time of the first diagnosis. |
| first_indexed | 2024-03-10T01:59:00Z |
| format | Article |
| id | doaj.art-92dfcd7b97ba4dd591fd5a8d48f57ab3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:59:00Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-92dfcd7b97ba4dd591fd5a8d48f57ab32023-11-23T12:51:06ZengMDPI AGCancers2072-66942022-08-011417417610.3390/cancers14174176Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the LiteratureStefano Restaino0Giorgia Dinoi1Eleonora La Fera2Benedetta Gui3Serena Cappuccio4Maura Campitelli5Giuseppe Vizzielli6Giovanni Scambia7Francesco Fanfani8Division of Obstetrics and Gynecology, University Hospital of Udine, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, ItalyDipartimento della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento Scienze della Vita e Sanità Pubblica, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyArea Diagnostica per Immagini, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyFondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radioterapia, Dipartimento di Scienze Radiologiche, Radioterapiche ed Ematologiche, 00168 Roma, ItalyDepartment of Medicinal Area (DAME) Clinic of Obstetrics and Gynecology, Santa Maria della Misericordia Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, ItalyDipartimento della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyDipartimento della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, ItalyBackground: Endometrial cancer is the most common gynaecological tumour in developed countries. The overall rate of relapse has remained unchanged in recent decades. Recurrences occur in approximately 20% of endometrioid and 50% of non-endometrioid cases. The aim of this systematic review is to compare different therapeutic strategies in the treatment of endometrial cancer recurrence to evaluate their prognostic and curative effects based on site and type of recurrence. Methods: This systematic review of literature was conducted in accordance with the PRISMA guidelines. The study protocol was registered on PROSPERO (CRD42020154042). PubMed, Embase, Chocrane and Cinahl databases were searched from January 1995 to September 2021. Five retrospective studies were selected. Results: A total of 3571 studies were included in the initial search. Applying the screening criteria, 299 articles were considered eligible for full-text reading, of which, after applying the exclusion criteria, 4 studies were selected for the final analysis and included in the systematic review. No studies were included for a quantitative analysis. We divided the results according to the location of the recurrence: locoregional recurrence, abdominal recurrence and extra abdominal recurrence. Conclusion: the treatment of choice should be assessed according to the relapse location and to the presence of single or multiple lesions. A crucial role in the decision-making algorithm is also the type of adjuvant treatment received at the time of the first diagnosis.https://www.mdpi.com/2072-6694/14/17/4176recurrent endometrial cancersecondary cytoreductive surgerychemotherapyradiotherapy |
| spellingShingle | Stefano Restaino Giorgia Dinoi Eleonora La Fera Benedetta Gui Serena Cappuccio Maura Campitelli Giuseppe Vizzielli Giovanni Scambia Francesco Fanfani Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature Cancers recurrent endometrial cancer secondary cytoreductive surgery chemotherapy radiotherapy |
| title | Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature |
| title_full | Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature |
| title_fullStr | Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature |
| title_full_unstemmed | Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature |
| title_short | Recurrent Endometrial Cancer: Which Is the Best Treatment? Systematic Review of the Literature |
| title_sort | recurrent endometrial cancer which is the best treatment systematic review of the literature |
| topic | recurrent endometrial cancer secondary cytoreductive surgery chemotherapy radiotherapy |
| url | https://www.mdpi.com/2072-6694/14/17/4176 |
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