Biochemistry-informed design selects potent siRNAs against SARS-CoV-2

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2

RNA interference (RNAi) offers an efficient way to repress genes of interest, and it is widely used in research settings. Clinical applications emerged more recently, with 5 approved siRNAs (the RNA guides of the RNAi effector complex) against human diseases. The development of siRNAs against the SA...

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Bibliographic Details
Main Authors: Élisabeth Houbron, Sophie Mockly, Sophia Rafasse, Nathalie Gros, Delphine Muriaux, Hervé Seitz
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:RNA Biology
Subjects:
sirna
rnai
sars-cov-2
sirna design
rna accessibility
Online Access:http://dx.doi.org/10.1080/15476286.2023.2217400

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