Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles
Curcumin displays anti-cancer, anti-inflammatory and anti-obesity properties but its water insolubility limits the wholesome utility. In this study, curcumin has been encapsulated in an amphiphilic biopolymer to enhance its water solubility. This was accomplished through self-assembly of octenyl suc...
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| Format: | Article |
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MDPI AG
2019-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/9/8/1073 |
| _version_ | 1828788801501134848 |
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| author | Zhongshan Hu Tao Feng Xiaolan Zeng Srinivas Janaswamy Hui Wang Osvaldo Campanella |
| author_facet | Zhongshan Hu Tao Feng Xiaolan Zeng Srinivas Janaswamy Hui Wang Osvaldo Campanella |
| author_sort | Zhongshan Hu |
| collection | DOAJ |
| description | Curcumin displays anti-cancer, anti-inflammatory and anti-obesity properties but its water insolubility limits the wholesome utility. In this study, curcumin has been encapsulated in an amphiphilic biopolymer to enhance its water solubility. This was accomplished through self-assembly of octenyl succinic anhydride−short glucan chains (OSA−SGC) and curcumin. The nanoparticles were prepared with the degree of substitution (DS) of 0.112, 0.286 and 0.342 of OSA. Thus prepared nanoparticles were in the range of 150−200 nm and display high encapsulation efficiency and high loading capacity of curcumin. The Fourier-transform infrared (FTIR) and X-ray diffraction analyses confirmed the curcumin loading in the OSA−SGC nanoparticles. The complexes possessed a V-type starch structure. The thermo gravimetric analysis (TGA) revealed the thermal stability of encapsulated curcumin. The OSA−SGC nanoparticles greatly improved the curcumin release and dissolution, and in-turn promoted the sustained release. |
| first_indexed | 2024-12-12T01:00:20Z |
| format | Article |
| id | doaj.art-92e3e3a2b2e84060a725dca0aed6c06a |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-12T01:00:20Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-92e3e3a2b2e84060a725dca0aed6c06a2022-12-22T00:43:45ZengMDPI AGNanomaterials2079-49912019-07-0198107310.3390/nano9081073nano9081073Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic NanoparticlesZhongshan Hu0Tao Feng1Xiaolan Zeng2Srinivas Janaswamy3Hui Wang4Osvaldo Campanella5School of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, ChinaSchool of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, ChinaSchool of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, ChinaDepartment of Dairy and Food Science, South Dakota State University, Brookings, SD 57007, USASchool of Perfume and Aroma Technology, Shanghai Institute of Technology, No. 100 Hai Quan Road, Shanghai 201418, ChinaBiological Engineering and Whistler Carbohydrate Research Center, Philip E. Nelson Hall of Food Science, Room 2195745 Agricultural Mall, Purdue University, West Lafayette, IN 47906, USACurcumin displays anti-cancer, anti-inflammatory and anti-obesity properties but its water insolubility limits the wholesome utility. In this study, curcumin has been encapsulated in an amphiphilic biopolymer to enhance its water solubility. This was accomplished through self-assembly of octenyl succinic anhydride−short glucan chains (OSA−SGC) and curcumin. The nanoparticles were prepared with the degree of substitution (DS) of 0.112, 0.286 and 0.342 of OSA. Thus prepared nanoparticles were in the range of 150−200 nm and display high encapsulation efficiency and high loading capacity of curcumin. The Fourier-transform infrared (FTIR) and X-ray diffraction analyses confirmed the curcumin loading in the OSA−SGC nanoparticles. The complexes possessed a V-type starch structure. The thermo gravimetric analysis (TGA) revealed the thermal stability of encapsulated curcumin. The OSA−SGC nanoparticles greatly improved the curcumin release and dissolution, and in-turn promoted the sustained release.https://www.mdpi.com/2079-4991/9/8/1073curcuminshort glucan chainsoctenyl succinic anhydrideamphiphilic biopolymerin vitro digestion |
| spellingShingle | Zhongshan Hu Tao Feng Xiaolan Zeng Srinivas Janaswamy Hui Wang Osvaldo Campanella Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles Nanomaterials curcumin short glucan chains octenyl succinic anhydride amphiphilic biopolymer in vitro digestion |
| title | Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles |
| title_full | Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles |
| title_fullStr | Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles |
| title_full_unstemmed | Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles |
| title_short | Structural Characterization and Digestibility of Curcumin Loaded Octenyl Succinic Nanoparticles |
| title_sort | structural characterization and digestibility of curcumin loaded octenyl succinic nanoparticles |
| topic | curcumin short glucan chains octenyl succinic anhydride amphiphilic biopolymer in vitro digestion |
| url | https://www.mdpi.com/2079-4991/9/8/1073 |
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