Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels
BackgroundNeuroactive steroids are endogenous molecules with regenerative and neuroprotective actions. Both cortical thickness and many neuroactive steroid levels decline with age and are decreased in several neuropsychiatric disorders. However, a systematic examination of the relationship between s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01118/full |
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| author | Rajendra A. Morey Rajendra A. Morey Rajendra A. Morey Sarah L. Davis Sarah L. Davis Courtney C. Haswell Courtney C. Haswell Jennifer C. Naylor Jennifer C. Naylor Jason D. Kilts Jason D. Kilts Steven T. Szabo Steven T. Szabo Larry J. Shampine Larry J. Shampine Gillian J. Parke Gillian J. Parke Delin Sun Delin Sun Chelsea A. Swanson Chelsea A. Swanson Henry R. Wagner Henry R. Wagner Henry R. Wagner Mid-Atlantic MIRECC Workgroup Christine E. Marx Christine E. Marx |
| author_facet | Rajendra A. Morey Rajendra A. Morey Rajendra A. Morey Sarah L. Davis Sarah L. Davis Courtney C. Haswell Courtney C. Haswell Jennifer C. Naylor Jennifer C. Naylor Jason D. Kilts Jason D. Kilts Steven T. Szabo Steven T. Szabo Larry J. Shampine Larry J. Shampine Gillian J. Parke Gillian J. Parke Delin Sun Delin Sun Chelsea A. Swanson Chelsea A. Swanson Henry R. Wagner Henry R. Wagner Henry R. Wagner Mid-Atlantic MIRECC Workgroup Christine E. Marx Christine E. Marx |
| author_sort | Rajendra A. Morey |
| collection | DOAJ |
| description | BackgroundNeuroactive steroids are endogenous molecules with regenerative and neuroprotective actions. Both cortical thickness and many neuroactive steroid levels decline with age and are decreased in several neuropsychiatric disorders. However, a systematic examination of the relationship between serum neuroactive steroid levels and in vivo measures of cortical thickness in humans is lacking.MethodsPeripheral serum levels of seven neuroactive steroids were assayed in United States military veterans. All (n = 143) subsequently underwent high-resolution structural MRI, followed by parcellelation of the cortical surface into 148 anatomically defined regions. Regression modeling was applied to test the association between neuroactive steroid levels and hemispheric total gray matter volume as well as region-specific cortical thickness. False discovery rate (FDR) correction was used to control for Type 1 error from multiple testing.ResultsNeuroactive steroid levels of allopregnanolone and pregnenolone were positively correlated with gray matter thickness in multiple regions of cingulate, parietal, and occipital association cortices (r = 0.20–0.47; p < 0.05; FDR-corrected).ConclusionPositive associations between serum neuroactive steroid levels and gray matter cortical thickness are found in multiple brain regions. If these results are confirmed, neuroactive steroid levels and cortical thickness may help in monitoring the clinical response in future intervention studies of neuroregenerative therapies. |
| first_indexed | 2024-12-12T20:31:19Z |
| format | Article |
| id | doaj.art-92e421589a49421eada6c07c94cef67a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T20:31:19Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-92e421589a49421eada6c07c94cef67a2022-12-22T00:13:00ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-11-011310.3389/fnins.2019.01118478416Widespread Cortical Thickness Is Associated With Neuroactive Steroid LevelsRajendra A. Morey0Rajendra A. Morey1Rajendra A. Morey2Sarah L. Davis3Sarah L. Davis4Courtney C. Haswell5Courtney C. Haswell6Jennifer C. Naylor7Jennifer C. Naylor8Jason D. Kilts9Jason D. Kilts10Steven T. Szabo11Steven T. Szabo12Larry J. Shampine13Larry J. Shampine14Gillian J. Parke15Gillian J. Parke16Delin Sun17Delin Sun18Chelsea A. Swanson19Chelsea A. Swanson20Henry R. Wagner21Henry R. Wagner22Henry R. Wagner23Mid-Atlantic MIRECC WorkgroupChristine E. Marx24Christine E. Marx25Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesBrain Imaging and Analysis Center, Duke University, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesBrain Imaging and Analysis Center, Duke University, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesBrain Imaging and Analysis Center, Duke University, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesBrain Imaging and Analysis Center, Duke University, Durham, NC, United StatesMid-Atlantic Mental Illness Research, Education and Clinical Center, Durham VA Medical Center, U.S. Department of Veteran Affairs, Durham, NC, United StatesDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United StatesBackgroundNeuroactive steroids are endogenous molecules with regenerative and neuroprotective actions. Both cortical thickness and many neuroactive steroid levels decline with age and are decreased in several neuropsychiatric disorders. However, a systematic examination of the relationship between serum neuroactive steroid levels and in vivo measures of cortical thickness in humans is lacking.MethodsPeripheral serum levels of seven neuroactive steroids were assayed in United States military veterans. All (n = 143) subsequently underwent high-resolution structural MRI, followed by parcellelation of the cortical surface into 148 anatomically defined regions. Regression modeling was applied to test the association between neuroactive steroid levels and hemispheric total gray matter volume as well as region-specific cortical thickness. False discovery rate (FDR) correction was used to control for Type 1 error from multiple testing.ResultsNeuroactive steroid levels of allopregnanolone and pregnenolone were positively correlated with gray matter thickness in multiple regions of cingulate, parietal, and occipital association cortices (r = 0.20–0.47; p < 0.05; FDR-corrected).ConclusionPositive associations between serum neuroactive steroid levels and gray matter cortical thickness are found in multiple brain regions. If these results are confirmed, neuroactive steroid levels and cortical thickness may help in monitoring the clinical response in future intervention studies of neuroregenerative therapies.https://www.frontiersin.org/article/10.3389/fnins.2019.01118/fullneuroactive steroidscortical thicknessMRIneuroregenerationneuroprotectiongray matter |
| spellingShingle | Rajendra A. Morey Rajendra A. Morey Rajendra A. Morey Sarah L. Davis Sarah L. Davis Courtney C. Haswell Courtney C. Haswell Jennifer C. Naylor Jennifer C. Naylor Jason D. Kilts Jason D. Kilts Steven T. Szabo Steven T. Szabo Larry J. Shampine Larry J. Shampine Gillian J. Parke Gillian J. Parke Delin Sun Delin Sun Chelsea A. Swanson Chelsea A. Swanson Henry R. Wagner Henry R. Wagner Henry R. Wagner Mid-Atlantic MIRECC Workgroup Christine E. Marx Christine E. Marx Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels Frontiers in Neuroscience neuroactive steroids cortical thickness MRI neuroregeneration neuroprotection gray matter |
| title | Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels |
| title_full | Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels |
| title_fullStr | Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels |
| title_full_unstemmed | Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels |
| title_short | Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels |
| title_sort | widespread cortical thickness is associated with neuroactive steroid levels |
| topic | neuroactive steroids cortical thickness MRI neuroregeneration neuroprotection gray matter |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.01118/full |
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