Association between SORL1 polymorphisms and the risk of Alzheimer's disease
A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nuc...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2018-05-01
|
| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1546080065308-550694410.pdf |
| _version_ | 1811289909052309504 |
|---|---|
| author | Lele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing Zhao |
| author_facet | Lele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing Zhao |
| author_sort | Lele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing Zhao |
| collection | DOAJ |
| description | A meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility in Asian populations, (ii) Single nucleotide polymorphism rs689021 was associated with decreased risk in Caucasians, and (iii) Single nucleotide polymorphism rs641120 was detected as a decreased risk in both populations. Given these data, crucial evidence is provided to demonstrate that a significant relationship exists between SORL1 polymorphisms and susceptibility to Alzheimer's disease. |
| first_indexed | 2024-04-13T04:02:24Z |
| format | Article |
| id | doaj.art-92e44ed165214e3eb7faf64afa09f353 |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-04-13T04:02:24Z |
| publishDate | 2018-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-92e44ed165214e3eb7faf64afa09f3532022-12-22T03:03:25ZengIMR PressJournal of Integrative Neuroscience1757-448X2018-05-0117218519210.31083/JIN-170051Association between SORL1 polymorphisms and the risk of Alzheimer's diseaseLele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing ZhaoA meta-analysis was performed to identify empirical data assessing the effects of a single nucleotide polymorphisms of sortilin-related receptor on Alzheimer's disease based on 14 studies involving 37941 cases and 49727 control studies. Analysis showed, (i) Increased risk between the single nucleotide polymorphisms (rs641120, rs1010159) and Alzheimer's disease susceptibility in Asian populations, (ii) Single nucleotide polymorphism rs689021 was associated with decreased risk in Caucasians, and (iii) Single nucleotide polymorphism rs641120 was detected as a decreased risk in both populations. Given these data, crucial evidence is provided to demonstrate that a significant relationship exists between SORL1 polymorphisms and susceptibility to Alzheimer's disease.https://jin.imrpress.com/fileup/1757-448X/PDF/1546080065308-550694410.pdf|alzheimer's disease|single nucleotide polymorphisms|sortilin-related receptor|neurogenomics|susceptibility|sortilin related receptor 1 |
| spellingShingle | Lele Cong, Xiangyi Kong, Jing Wang, Jianshi Du, Zhongxin Xu, Yanan Xu, Qing Zhao Association between SORL1 polymorphisms and the risk of Alzheimer's disease Journal of Integrative Neuroscience |alzheimer's disease|single nucleotide polymorphisms|sortilin-related receptor|neurogenomics|susceptibility|sortilin related receptor 1 |
| title | Association between SORL1 polymorphisms and the risk of Alzheimer's disease |
| title_full | Association between SORL1 polymorphisms and the risk of Alzheimer's disease |
| title_fullStr | Association between SORL1 polymorphisms and the risk of Alzheimer's disease |
| title_full_unstemmed | Association between SORL1 polymorphisms and the risk of Alzheimer's disease |
| title_short | Association between SORL1 polymorphisms and the risk of Alzheimer's disease |
| title_sort | association between sorl1 polymorphisms and the risk of alzheimer s disease |
| topic | |alzheimer's disease|single nucleotide polymorphisms|sortilin-related receptor|neurogenomics|susceptibility|sortilin related receptor 1 |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1546080065308-550694410.pdf |
| work_keys_str_mv | AT lelecongxiangyikongjingwangjianshiduzhongxinxuyananxuqingzhao associationbetweensorl1polymorphismsandtheriskofalzheimersdisease |